Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Immunology Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Nat Med. 2017 Mar 7;23(3):279-287. doi: 10.1038/nm.4294.
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this process might also occur in noninfectious, sterile inflammation. In this Review, we describe the role of NETosis in autoimmunity, coagulation, acute injuries and cancer, and discuss NETs as potential therapeutic targets. Furthermore, we consider whether extracellular DNA is always detrimental in sterile inflammation and whether the source is always NETs.
中性粒细胞胞外诱捕网（NETs）的产生是一种能够帮助中性粒细胞捕捉和杀死细菌的过程。然而，越来越多的证据表明，这一过程也可能发生在非传染性的无菌性炎症中。在这篇综述中，我们描述了 NETosis 在自身免疫、凝血、急性损伤和癌症中的作用，并讨论了 NETs 作为潜在的治疗靶点。此外，我们还考虑了在无菌性炎症中，细胞外 DNA 是否总是有害的，以及其来源是否总是 NETs。
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