Brave Michael A, Lakkireddy Dhanunjaya R, Kroll Mark W, Panescu Dorin
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:2343-2348. doi: 10.1109/EMBC.2016.7591200.
Small swine are the most common model now used for electrical safety studies. Because of the significant anatomical and electrophysiological differences and the effect of animal size on the ventricular fibrillation (VF) threshold, there are concerns that these differences may exaggerate the risks of electrical devices to humans. We chose, as an illustrative and relevant example, swine studies of the TASER® conducted electrical weapon (CEW) as it has numerous published VF studies. We reviewed the published electrical swine safety studies for CEWs and compared them to finite element modeling studies, electrical safety standards, and epidemiological experience from field usage. We also compared the body weights of the swine to those of law enforcement arrest-related deaths. Studies of small swine exaggerate the risks of CEWs to humans. This conclusion may be extrapolated to suggest that the use of small swine for electrical safety studies should be questioned in general.
小型猪是目前电气安全研究中最常用的模型。由于存在显著的解剖学和电生理学差异,以及动物体型对室颤(VF)阈值的影响,人们担心这些差异可能会夸大电气设备对人类的风险。作为一个具有说明性和相关性的例子,我们选择了对泰瑟枪®这种电击武器(CEW)进行的猪实验,因为有大量关于其室颤的已发表研究。我们回顾了已发表的关于CEW的猪电气安全研究,并将其与有限元建模研究、电气安全标准以及现场使用的流行病学经验进行了比较。我们还将猪的体重与执法逮捕相关死亡案例中的人类体重进行了比较。对小型猪的研究夸大了CEW对人类的风险。这一结论可能会被外推,以表明一般来说,在电气安全研究中使用小型猪的做法应受到质疑。