Mei Li-Li, Qiu Yun-Tan, Zhang Bing, Shi Zhi-Zhou
Cancer Biomark. 2017;19(1):1-9. doi: 10.3233/CBM-160240.
Esophageal cancer is a common cause of cancer-related deaths worldwide. Squamous cell carcinoma (SCC) is the major histological type of esophageal cancer in developing countries including China, and the prognosis is very poor. Many microRNAs are involved in several important biological and pathologic processes, and promote tumorigenesis. To better understand the prognostic and therapeutic roles of microRNAs in ESCC, we reviewed the diagnosis and prognosis associated oncogenic microRNAs (e.g. miR-21 and miR-17-92 cluster) and tumor suppressor microRNAs (e.g. miR-375, miR-133a and miR-133b), and diagnosis and prognosis associated oncogenic target genes (e.g. PDCD4 and CCND1) and tumor suppressor target genes (e.g. EZH2 and PDK1). We also summarized the prognostic microRNA and target gene pairs (e.g. miR-296 and CCND1, miR214 and EZH2). Taken together, our review highlights the opportunities and challenges for microRNAs in the molecular diagnosis and target therapy of ESCC.
食管癌是全球癌症相关死亡的常见原因。鳞状细胞癌（SCC）是包括中国在内的发展中国家食管癌的主要组织学类型，预后很差。许多微小RNA参与了多个重要的生物学和病理过程，并促进肿瘤发生。为了更好地了解微小RNA在食管鳞状细胞癌（ESCC）中的预后和治疗作用，我们综述了与诊断和预后相关的致癌性微小RNA（如miR-21和miR-17-92簇）和抑癌性微小RNA（如miR-375、miR-133a和miR-133b），以及与诊断和预后相关的致癌性靶基因（如PDCD4和CCND1）和抑癌性靶基因（如EZH2和PDK1）。我们还总结了预后性微小RNA和靶基因对（如miR-296和CCND1、miR214和EZH2）。综上所述，我们的综述突出了微小RNA在ESCC分子诊断和靶向治疗中的机遇与挑战。
