Department of Oncology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China.
Department of Pediatric Surgery, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, China.
Cells. 2022 Dec 28;12(1):114. doi: 10.3390/cells12010114.
Esophageal cancer is one of the malignant tumors with poor prognosis in China. Currently, the treatment of esophageal cancer is still based on surgery, especially in early and mid-stage patients, to achieve the goal of radical cure. However, esophageal cancer is a kind of tumor with a high risk of recurrence and metastasis, and locoregional recurrence and distant metastasis are the leading causes of death after surgery. Although multimodal comprehensive treatment has advanced in recent years, the prediction, prevention and treatment of postoperative recurrence and metastasis of esophageal cancer are still unsatisfactory. How to reduce recurrence and metastasis in patients after surgery remains an urgent problem to be solved. Given the clinical demand for early detection of postoperative recurrence of esophageal cancer, clinical and basic research aiming to meet this demand has been a hot topic, and progress has been observed in recent years. Therefore, this article reviews the research progress on the factors that influence and predict postoperative recurrence of esophageal cancer, hoping to provide new research directions and treatment strategies for clinical practice.
食管癌是中国预后较差的恶性肿瘤之一。目前，食管癌的治疗仍以手术为主，尤其是早期和中期患者，以达到根治的目的。然而，食管癌是一种复发和转移风险较高的肿瘤，局部复发和远处转移是手术后死亡的主要原因。尽管近年来多模式综合治疗有所进展，但食管癌术后复发和转移的预测、预防和治疗仍不尽如人意。如何降低术后患者的复发和转移率仍是亟待解决的问题。鉴于临床对食管癌术后复发的早期检测需求，针对这一需求的临床和基础研究一直是一个热点，近年来也取得了一些进展。因此，本文就影响和预测食管癌术后复发的相关因素的研究进展进行综述，以期为临床实践提供新的研究方向和治疗策略。
