Takeuchi Naoyuki, Izumi Shin-Ichi
Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine.
Brain Nerve. 2017 Mar;69(3):227-238. doi: 10.11477/mf.1416200732.
Various novel stroke rehabilitative methods have been developed based on findings in basic science and clinical research. Recently, many reports have shown that repetitive transcranial magnetic stimulation (rTMS) improves function in stroke patients by altering the excitability of the human cortex. The interhemispheric competition model proposes that deficits in stroke patients are due to reduced output from the affected hemisphere and excessive interhemispheric inhibition from the unaffected hemisphere to the affected hemisphere. The interhemispheric competition model indicates that improvement in deficits can be achieved either by increasing the excitability of the affected hemisphere using excitatory rTMS or by decreasing the excitability of the unaffected hemisphere using inhibitory rTMS. Recovery after stroke is related to neural plasticity, which involves developing new neural connections, acquiring new functions, and compensating for impairments. Artificially modulating the neural network by rTMS may induce a more suitable environment for use-dependent plasticity and also may interfere with maladaptive neural activation, which weakens function and limits recovery. There is potential, therefore, for rTMS to be used as an adjuvant therapy for developed neurorehabilitation techniques in stroke patients.
基于基础科学和临床研究的结果,已经开发出了各种新颖的中风康复方法。最近,许多报告表明,重复经颅磁刺激(rTMS)通过改变人类皮层的兴奋性来改善中风患者的功能。半球间竞争模型提出,中风患者的功能缺陷是由于患侧半球输出减少以及健侧半球对患侧半球的半球间抑制过度所致。半球间竞争模型表明,通过使用兴奋性rTMS提高患侧半球的兴奋性或通过使用抑制性rTMS降低健侧半球的兴奋性,可以实现功能缺陷的改善。中风后的恢复与神经可塑性有关,神经可塑性涉及建立新的神经连接、获得新功能以及补偿损伤。通过rTMS人工调节神经网络可能会诱导出一个更适合使用依赖性可塑性的环境,也可能会干扰适应不良的神经激活,而这种神经激活会削弱功能并限制恢复。因此,rTMS有潜力作为中风患者已有的神经康复技术的辅助治疗方法。