de Oliveira Sandra R P, Nomizo Auro, Frantz Fabiani G, Faccioli Lúcia H, de Matos Ana Paula Keller, Carrilho Emanuel, Afonso Ana, de Freitas Anibal Fernanda
Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos São Carlos, Brazil.
Faculdade de Ciências Farmacêuticas de Ribeirão Preto - University of São Paulo Ribeirão Preto, Brazil.
Front Microbiol. 2017 Feb 21;8:242. doi: 10.3389/fmicb.2017.00242. eCollection 2017.
Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role in the induction of OT, as well as, the production of cytokines IL-5 and IFN-γ in leukotriene deficient animals (knock-out). Our results suggested that even in the presence of OT and leukotrienes absence, cytokine IFN-γ remains being secreted, which gives us an indication of immune system specificity and also that IFN-γ participates in various immune processes.
口服耐受（OT）的特征是一种外周免疫耐受形式，其中，由于先前口服抗原，与粘膜相关的淋巴组织中的成熟淋巴细胞变得无功能或反应低下。由于其在炎症过程和其他疾病中的治疗潜力，OT是一种重要的免疫现象。在这里，我们评估了白三烯在OT诱导中的作用，以及白三烯缺陷动物（基因敲除）中细胞因子IL-5和IFN-γ的产生。我们的结果表明，即使在存在OT且缺乏白三烯的情况下，细胞因子IFN-γ仍会分泌，这为我们提供了免疫系统特异性的指示，也表明IFN-γ参与了各种免疫过程。
