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1
Contrasting observations on buffer catalysis of guanosine amino proton exchange.关于鸟苷氨基质子交换的缓冲催化的对比观察。
Nucleic Acids Res. 1987 Dec 10;15(23):10007-20. doi: 10.1093/nar/15.23.10007.
2
Exceptional characteristics of amino proton exchange in guanosine compounds.鸟苷化合物中氨基质子交换的特殊性质。
Biochemistry. 1983 Jun 21;22(13):3033-7. doi: 10.1021/bi00282a001.
3
Exchange mechanisms for hydrogen bonding protons of cytidylic and guanylic acids.胞苷酸和鸟苷酸氢键质子的交换机制。
Biochemistry. 1978 Jul 25;17(15):3168-76. doi: 10.1021/bi00608a035.
4
Helix opening in deoxyribonucleic acid from a proton nuclear magnetic resonance study of imino and amino protons in d(CG)3.通过对d(CG)3中亚氨基和氨基质子的质子核磁共振研究得出的脱氧核糖核酸中的螺旋开口
Nucleic Acids Res. 1984 Nov 12;12(21):8269-79. doi: 10.1093/nar/12.21.8269.
5
Internal motions of transfer RNA: a study of exchanging protons by magnetic resonance.转运核糖核酸的内部运动：通过磁共振交换质子的研究
J Biomol Struct Dyn. 1985 Feb;2(5):915-39. doi: 10.1080/07391102.1985.10507609.
6
Structure sensitivity of amino proton exchange in 2'- and 5' - guanosine monophosphate dianions.2'-和5'-鸟苷单磷酸二价阴离子中氨基质子交换的结构敏感性
J Biomol Struct Dyn. 1994 Dec;12(3):681-94. doi: 10.1080/07391102.1994.10508767.
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Biochemistry. 1985 Jul 2;24(14):3603-9. doi: 10.1021/bi00335a031.
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Buffer catalysis of amino proton exchange in compounds of adenosine, cytidine and their endocyclic N-methylated derivatives.腺苷、胞苷及其内环N-甲基化衍生物化合物中氨基质子交换的缓冲催化作用。
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9
Guanine and 7-methylguanine amino proton exchange rates as a function of buffer pK: implications for the exchange mechanism.鸟嘌呤和7-甲基鸟嘌呤的氨基质子交换速率与缓冲液pK的关系：对交换机制的启示
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NMR study of slowly exchanging imino protons in yeast tRNAasp.酵母天冬氨酸转运核糖核酸中缓慢交换亚氨基质子的核磁共振研究
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4330-3. doi: 10.1073/pnas.80.14.4330.

本文引用的文献

1
Buffer catalysis of amino proton exchange in compounds of adenosine, cytidine and their endocyclic N-methylated derivatives.腺苷、胞苷及其内环N-甲基化衍生物化合物中氨基质子交换的缓冲催化作用。
Biophys Chem. 1984 Aug;20(1-2):135-48. doi: 10.1016/0301-4622(84)80013-7.
2
The amino 1H resonances of oligonucleotide helices: d(CGCG).寡核苷酸螺旋的氨基 1H 共振：d(CGCG)
J Biomol Struct Dyn. 1984 Jun;1(6):1407-21. doi: 10.1080/07391102.1984.10507528.
3
Exceptional characteristics of amino proton exchange in guanosine compounds.鸟苷化合物中氨基质子交换的特殊性质。
Biochemistry. 1983 Jun 21;22(13):3033-7. doi: 10.1021/bi00282a001.
4
Hydrogen exchange and structural dynamics of proteins and nucleic acids.蛋白质和核酸的氢交换与结构动力学
Q Rev Biophys. 1983 Nov;16(4):521-655. doi: 10.1017/s0033583500005217.
5
Imidazole catalysis of amino proton exchange in 2',3'-cyclic adenosine monophosphate. A general exchange mechanism.咪唑催化2',3'-环磷酸腺苷中氨基质子的交换。一种通用的交换机制。
Biochemistry. 1974 Oct 22;13(22):4516-23. doi: 10.1021/bi00719a007.
6
Amino protons of cytosine. Chemical exchange, rotational exchange, and salt-induced proton magnetic resonance chemical shifts of aqueous 2',3'-cyclic cytidine monophosphate.胞嘧啶的氨基质子。2',3'-环胞苷单磷酸盐水溶液的化学交换、旋转交换和盐诱导的质子磁共振化学位移。
Biochemistry. 1973 Oct 23;12(22):4426-34. doi: 10.1021/bi00746a020.
7
Proton exchange of nucleic acids. Amino protons of mononucleotides.
Biochemistry. 1972 Nov 7;11(23):4382-92. doi: 10.1021/bi00773a027.
8
General acid-base catalysis in nucleobase amino proton exchange: cytidine.核碱基氨基质子交换中的一般酸碱催化：胞苷
J Biomol Struct Dyn. 1986 Dec;4(3):419-36. doi: 10.1080/07391102.1986.10506359.
9
Guanine and 7-methylguanine amino proton exchange rates as a function of buffer pK: implications for the exchange mechanism.鸟嘌呤和7-甲基鸟嘌呤的氨基质子交换速率与缓冲液pK的关系：对交换机制的启示
Nucleic Acids Res. 1986 Sep 11;14(17):7083-92.
10
Letter: Self-assembled 5'-guanosine monophosphate. Nuclear magnetic resonance evidence for a regular, ordered structure and slow chemical exchange.信函：自组装5'-鸟苷单磷酸。具有规则有序结构和缓慢化学交换的核磁共振证据。
J Am Chem Soc. 1975 Nov 26;97(24):7198-200. doi: 10.1021/ja00857a059.

关于鸟苷氨基质子交换的缓冲催化的对比观察。

Contrasting observations on buffer catalysis of guanosine amino proton exchange.

作者信息

McConnell B

机构信息

Department of Biochemistry and Biophysics, John A. Burns School of Medicine, Honolulu, HA 96822.

出版信息

Nucleic Acids Res. 1987 Dec 10;15(23):10007-20. doi: 10.1093/nar/15.23.10007.

DOI:10.1093/nar/15.23.10007
PMID:2827102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC306547/
Abstract

The two amino protons of 3', 5'-cyclic guanosine monophosphate are shown to differ drastically in their solvent exchange properties: One is rapidly exchanging and sensitive to buffer catalysis; the other slow and insensitive. This observation accounts for the marked contrast between stopped-flow and NMR observations on buffer catalysis of amino proton exchange in guanosine monophosphates. The amino protons of guanine compounds traverse a "fast" solvent exchange position through the process of amino rotation, which together with kinetic considerations and comparative data on adenine and cytosine compounds, supports proposals of solvent exchange mediated by events at the guanine (N-3) site, rather than the (N-7) site. Exchange does not conform to rate expressions used by different workers for amino proton exchange.

摘要

3',5'-环磷酸鸟苷的两个氨基质子在溶剂交换性质上表现出极大差异：一个快速交换且对缓冲液催化敏感；另一个缓慢且不敏感。这一观察结果解释了在鸟苷单磷酸氨基质子交换的缓冲液催化方面，停流法和核磁共振观察结果之间的显著差异。鸟嘌呤化合物的氨基质子通过氨基旋转过程穿越一个“快速”溶剂交换位置，这与动力学考虑以及腺嘌呤和胞嘧啶化合物的比较数据一起，支持了由鸟嘌呤（N-3）位点而非（N-7）位点的事件介导溶剂交换的提议。交换不符合不同研究者用于氨基质子交换的速率表达式。