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4-氮杂三环[5.2.2.0(2,6)]十一烷-8-烯-3,5-二酮硫脲衍生物的合成与微生物活性。

Synthesis and microbiological activity of thiourea derivatives of 4-azatricyclo[5.2.2.0(2,6)]undec-8-ene-3,5-dione.

机构信息

Medical University, Department of Medical Chemistry, 3 Oczki Str., 02-007 Warsaw, Poland.

出版信息

Arch Pharm Res. 2010 Jan;33(1):47-54. doi: 10.1007/s12272-010-2223-9. Epub 2010 Feb 27.

Abstract

A series of thiourea derivatives of 4-azatricyclo[5.2.2.0(2,6)]undec-8-ene-3,5-dione were synthesized. The compounds were investigated for antibacterial activity, including Gram-positive cocci, Gram-negative rods, and antifungal activity. Compounds 1b, 2b, 4b showed significant inhibition against Gram-positive cocci. Research was carried out over 10 standard strains and 20 hospital strains. Synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.

摘要

合成了一系列 4-氮杂三环[5.2.2.0(2,6)]十一碳-8-烯-3,5-二酮的硫脲衍生物。研究了这些化合物的抗菌活性,包括革兰氏阳性球菌、革兰氏阴性杆菌和抗真菌活性。化合物 1b、2b、4b 对革兰氏阳性球菌表现出显著的抑制作用。研究针对 10 个标准菌株和 20 个医院分离株进行。评估了合成化合物对 MT-4 细胞的细胞毒性和抗 HIV-1 活性。

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