预测脂肪纤维化。
Forecasting Fat Fibrosis.
机构信息
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Cell Metab. 2017 Mar 7;25(3):493-494. doi: 10.1016/j.cmet.2017.02.019.
Excess ECM and fibrosis of white adipose tissue (WAT) is associated with tissue dysfunction and type 2 diabetes. In this issue of Cell Metabolism, Marcelin et al. (2017) elucidate a key mechanism behind WAT fibrosis in which the activation of PDGFRα on adipocyte precursors drives this population toward a fibrotic phenotype.
细胞外基质（ECM）过剩和白色脂肪组织（WAT）纤维化与组织功能障碍和 2 型糖尿病有关。在本期《细胞代谢》中，Marcelin 等人阐明了 WAT 纤维化背后的一个关键机制，即脂肪细胞前体细胞上 PDGFRα 的激活促使该细胞群向纤维表型发展。
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