Duane G B, Kanter M H, Branigan T, Chang C
Department of Pathology, Harbor-UCLA Medical Center, Torrance.
Acta Cytol. 1987 Nov-Dec;31(6):742-50.
Morphologic and morphometric studies were carried out on eight cases of pure and mixed colloid carcinoma of the breast initially diagnosed by fine needle aspiration (FNA). Key morphologic features included (1) cellular smears, (2) single cells, loose aggregates and cohesive groups of cells bathed in a mucinous background, (3) single cells displaying nuclear eccentricity and (4) little variation in nuclear size or shape, with bland-to-accentuated chromatin and rare nucleoli. These morphologic features are compared with those observed in pregnancy adenoma, lobular carcinoma, fibroadenoma, ductal carcinoma and medullary carcinoma. A morphometric study employing the major and minor axes of the nucleus, its axis product and axis ratio was also performed. Statistical treatment confirmed that the nuclear axis product (a size factor) distinguished colloid carcinoma from the other breast lesions, except the small-cell type of ductal carcinoma. Furthermore, the nuclear axis ratio (a shape factor) discriminates pregnancy adenoma and small-cell ductal carcinoma from the other breast lesions studied. By combining morphologic and morphometric criteria, one can specifically separate colloid carcinoma from the other breast lesions when examining smears obtained by FNA. Since colloid carcinoma is usually composed of cells with a relatively benign-appearing cytomorphology, the importance of recognizing this entity in fine needle aspirates is emphasized.
对最初通过细针穿刺（FNA）诊断的8例纯乳腺黏液癌和混合性乳腺黏液癌进行了形态学和形态计量学研究。关键的形态学特征包括：（1）细胞涂片；（2）单个细胞、松散聚集的细胞及紧密相连的细胞团，浸浴在黏液背景中；（3）单个细胞显示核偏心；（4）核大小或形状变化小，染色质从平淡到明显，核仁罕见。将这些形态学特征与妊娠腺瘤、小叶癌、纤维腺瘤、导管癌和髓样癌中观察到的特征进行比较。还进行了一项形态计量学研究，测量细胞核的长轴和短轴、轴乘积及轴比。统计学处理证实，核轴乘积（一个大小因子）可将黏液癌与其他乳腺病变区分开来，但小细胞型导管癌除外。此外，核轴比（一个形状因子）可将妊娠腺瘤和小细胞导管癌与所研究的其他乳腺病变区分开来。通过结合形态学和形态计量学标准，在检查FNA涂片时，可将黏液癌与其他乳腺病变明确区分开来。由于黏液癌通常由细胞形态相对良性的细胞组成，因此强调了在细针穿刺抽吸物中识别该实体的重要性。
