Karpuz Derya, Hallioglu Olgu, Toros Fevziye, Tasdelen Bahar
Mersin University, Faculty of Medicine, Department of Pediatric Cardiology, TR, Mersin, Turkey.
Mersin University, Faculty of Medicine, Department of Pediatric Cardiology, TR, Mersin, Turkey.
J Electrocardiol. 2017 Jul-Aug;50(4):410-415. doi: 10.1016/j.jelectrocard.2017.02.012. Epub 2017 Feb 20.
This study is to investigate ventricular repolarization on electrocardiogram (ECG) in a pediatric population receiving methylphenidate (MPH), risperidone (RIS) and combined therapy.
A total of 215 patients between 6 and 12years with ADHD/conduct disorder receiving methylphenidate, risperidone and combined therapy for minimum 3months and an untreated ADHD group (n=76) was consecutively included in the study. Twelve lead ECG parameters including mean QT, QTc, T-peak to T-end (TpTe) intervals, TpTe dispersion and TpTe/QT ratio were compared.
QT interval, and QTc, TpTe interval, TpTe dispersion and TpTe/QTc ratio values for groups receiving RIS, MPH and combined therapy were found to be significantly higher than other groups. Moreover, in the combined therapy group TpTe and TpTe/QTc values were higher than the single drug administration groups (p<0.05). TpTe and TpTe/QT ratio was significantly higher in the RIS group compared to that of the MPH group.
These results suggested that combined therapy of these drugs had a more prominent impact on the T wave and RIS could be strongly associated with it.
本研究旨在调查接受哌甲酯（MPH）、利培酮（RIS）及联合治疗的儿科患者心电图（ECG）上的心室复极情况。
共有215例6至12岁患有注意力缺陷多动障碍/品行障碍的患者连续纳入本研究，这些患者接受哌甲酯、利培酮及联合治疗至少3个月，还有一个未治疗的注意力缺陷多动障碍组（n = 76）。比较了包括平均QT、QTc、T波峰至T波终末（TpTe）间期、TpTe离散度和TpTe/QT比值在内的12导联心电图参数。
发现接受RIS、MPH及联合治疗组的QT间期、QTc、TpTe间期、TpTe离散度和TpTe/QTc比值显著高于其他组。此外，联合治疗组的TpTe和TpTe/QTc值高于单药治疗组（p<0.05）。与MPH组相比，RIS组的TpTe和TpTe/QT比值显著更高。
这些结果表明，这些药物的联合治疗对T波有更显著的影响，且RIS可能与之密切相关。
