外周炎症标志物提示阿尔茨海默病脑室周围白质高信号内的微观结构损伤：初步报告。
Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report.
作者信息
Swardfager Walter, Yu Di, Ramirez Joel, Cogo-Moreira Hugo, Szilagyi Gregory, Holmes Melissa F, Scott Christopher J M, Scola Gustavo, Chan Pak C, Chen Jialun, Chan Parco, Sahlas Demetrios J, Herrmann Nathan, Lanctôt Krista L, Andreazza Ana C, Pettersen Jacqueline A, Black Sandra E
机构信息
Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada; LC Campbell Cognitive Neurology Unit, Sunnybrook Research Institute, Toronto, Ontario, Canada; University Health Network Toronto Rehabilitation Institute, Toronto, Ontario, Canada.
Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada; Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada; LC Campbell Cognitive Neurology Unit, Sunnybrook Research Institute, Toronto, Ontario, Canada.
出版信息
Alzheimers Dement (Amst). 2017 Jan 21;7:56-60. doi: 10.1016/j.dadm.2016.12.011. eCollection 2017.
INTRODUCTION
White matter hyperintensities (WMH) presumed to reflect cerebral small vessel disease and increased peripheral inflammatory markers are found commonly in Alzheimer's disease (AD), but their interrelationships remain unclear.
METHODS
Inflammatory markers were assayed in 54 elderly participants ( = 16 with AD). Periventricular WMH were delineated from T1, T2/proton density, and fluid-attenuated magnetic resonance imaging using semiautomated fuzzy lesion extraction and coregistered with maps of fractional anisotropy (FA), a measure of microstructural integrity assessed using diffusion tensor imaging.
RESULTS
Mean FA within periventricular WMH was associated with an inflammatory factor consisting of interleukin (IL)-1β, tumor necrosis factor, IL-10, IL-21, and IL-23 in patients with AD (ρ = -0.703, = .002) but not in healthy elderly (ρ = 0.217, = .190). Inflammation was associated with greater FA in deep WMH in healthy elderly (ρ = 0.425, = .008) but not in patients with AD (ρ = 0.174, = .520).
DISCUSSION
Peripheral inflammatory markers may be differentially related to microstructural characteristics within the white matter affected by cerebral small vessel disease in elders with and without AD.
引言
白质高信号（WMH）被认为反映了脑小血管疾病，且在阿尔茨海默病（AD）中常见外周炎症标志物升高，但其相互关系仍不清楚。
方法
对54名老年参与者（其中16名患有AD）的炎症标志物进行检测。使用半自动模糊病变提取方法，从T1、T2/质子密度和液体衰减磁共振成像中勾勒出脑室周围白质高信号，并与分数各向异性（FA）图配准，FA是一种使用扩散张量成像评估的微观结构完整性指标。
结果
AD患者脑室周围白质高信号内的平均FA与由白细胞介素（IL）-1β、肿瘤坏死因子、IL-10、IL-21和IL-23组成的炎症因子相关（ρ = -0.703，P = 0.002），而在健康老年人中无相关性（ρ = 0.217，P = 0.190）。炎症与健康老年人深部白质高信号中较高的FA相关（ρ = 0.425，P = 0.008），但在AD患者中无相关性（ρ = 0.174，P = 0.520）。
讨论
外周炎症标志物可能与患有和未患有AD的老年人脑小血管疾病影响的白质内微观结构特征存在不同关系。
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