Lee Kyung Mi, Kim Sang Tae, Tian Yunan, Jung Sue Min, Chang Yunjung, Rhee Hak Young, Park Soonchan, Ryu Chang-Woo, Lee Woo-In, Kim Eui Jong, Jahng Geon-Ho
Department of Radiology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
JN Pharma, Seongnam-si, Republic of Korea.
Front Aging Neurosci. 2024 Jul 23;16:1388654. doi: 10.3389/fnagi.2024.1388654. eCollection 2024.
Blood inflammatory biomarkers have emerged as important tools for diagnosing, assessing treatment responses, and predicting neurodegenerative diseases. This study evaluated the associations between blood inflammatory biomarkers and brain tissue volume loss in elderly people.
This study included 111 participants (age 67.86 ± 8.29 years; 32 men and 79 women). A battery of the following blood inflammatory biomarkers was measured, including interleukin 1-beta (IL1β), NACHT, LRR, and PYD domains-containing protein 3 (NLRP3), monomer Aβ42 (mAβ), oligomeric Aβ42 (oAβ), miR155, neurite outgrowth inhibitor A (nogo-A), phosphorylated tau (P-tau), and total tau (T-tau). Three-dimensional T1-weight images (3D T1WI) of all participants were prospectively obtained and segmented into gray matter and white matter to measure the gray matter volume (GMV), white matter volume (WMV), and gray-white matter boundary tissue volume (gwBTV). The association between blood biomarkers and tissue volumes was assessed using voxel-based and region-of-interest analyses.
GMV and gwBTV significantly decreased as the levels of IL1β and T-tau increased, while no significant association was found between the level of P-tau and the three brain tissue volumes. Three brain tissue volumes were negatively correlated with the levels of IL1β, P-tau, and T-tau in the hippocampus. Specifically, IL1β and T-tau levels showed a distinct negative association with the three brain tissue volume losses in the hippocampus. In addition, gwBTV was negatively associated with the level of NLRP3.
The observed association between brain tissue volume loss and elevated levels of IL1β and T-tau suggests that these biomarkers in the blood may serve as potential biomarkers of cognitive impairment in elderly people. Thus, IL1β and T-tau could be used to assess disease severity and monitor treatment response after diagnosis in elderly people who are at risk of cognitive decline.
血液炎症生物标志物已成为诊断、评估治疗反应和预测神经退行性疾病的重要工具。本研究评估了老年人血液炎症生物标志物与脑组织体积减少之间的关联。
本研究纳入了111名参与者（年龄67.86±8.29岁；男性32名，女性79名）。检测了一系列血液炎症生物标志物，包括白细胞介素1-β（IL1β）、含NACHT、LRR和PYD结构域的蛋白3（NLRP3）、单体Aβ42（mAβ）、寡聚体Aβ42（oAβ）、miR155、神经突生长抑制因子A（nogo-A）、磷酸化tau蛋白（P-tau）和总tau蛋白（T-tau）。前瞻性地获取了所有参与者的三维T1加权图像（3D T1WI），并将其分割为灰质和白质，以测量灰质体积（GMV）、白质体积（WMV）和灰白质边界组织体积（gwBTV）。使用基于体素和感兴趣区域分析评估血液生物标志物与组织体积之间的关联。
随着IL1β和T-tau水平升高，GMV和gwBTV显著降低，而P-tau水平与三种脑组织体积之间未发现显著关联。三种脑组织体积与海马体中IL1β、P-tau和T-tau水平呈负相关。具体而言，IL1β和T-tau水平与海马体中三种脑组织体积减少呈明显负相关。此外，gwBTV与NLRP3水平呈负相关。
观察到的脑组织体积减少与IL1β和T-tau水平升高之间的关联表明，血液中的这些生物标志物可能是老年人认知障碍的潜在生物标志物。因此，IL1β和T-tau可用于评估有认知衰退风险的老年人的疾病严重程度，并在诊断后监测治疗反应。
