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2001年至2011年芬兰图尔库死产的原因

Causes of Stillbirth in Turku, Finland, 2001-2011.

作者信息

Lehtonen Tanita, Markkula Tuomas, Soidinsalo Pasi, Otonkoski Saara, Laine Jukka

机构信息

1 Department of Pathology, University of Turku and TYKS-SAPA, Turku University Hospital, Turku, Finland.

2 Department of Obstetrics and Gynecology, Satakunta Central Hospital, Pori, Finland.

出版信息

Pediatr Dev Pathol. 2017 Jan-Feb;20(1):5-15. doi: 10.1177/1093526616686236.

Abstract

The objective of the study was to examine the causes of stillbirth in the district of Southwest Finland and to assess the importance of postmortem examination and the selection of a suitable classification system for classifying stillbirths. This study is a cohort study where the fetal autopsies were performed in the Department of Pathology at Turku University Hospital, Finland, 2001-2011. Stillbirths from singleton pregnancies at the gestational age of ≥ 24 + 0 weeks (if unknown, gestational weight ≥ 500 g) (n = 98) were selected. In addition, stillbirths from multiple gestations (n = 6) were also analyzed. The causes of stillbirths were classified according to the Relevant Condition at Death classification system. Maternal risk factors and the role of fetal gestational age and weight for the causes of stillbirth were assessed. The most common causes of singleton stillbirth were lethal congenital anomalies, placental insufficiencies, and constricting loops and knots of the umbilical cord. The cause of singleton stillbirth could be determined for 78% of the cases, leaving 22% unclassified. There were no significant differences in the causes of stillbirth by gestational age or weight. Smoking may increase the incidence of placental abruption ( P < 0.01). The most common causes of stillbirth in Turku, Finland, are consistent with findings from other high-income countries. With careful postmortem examination and ancillary studies, it is possible to find the cause of stillbirth for most of the cases. Even if the stillbirth is left unexplained, many other harmful conditions can be excluded thus benefiting both the parents and the health care unit.

摘要

本研究的目的是调查芬兰西南部地区死产的原因,并评估尸体解剖的重要性以及选择合适的分类系统对死产进行分类。本研究是一项队列研究,2001年至2011年期间在芬兰图尔库大学医院病理科进行了胎儿尸检。选取了孕龄≥24+0周(若孕周未知,出生体重≥500g)的单胎妊娠死产病例(n=98)。此外,还分析了多胎妊娠死产病例(n=6)。根据死亡相关情况分类系统对死产原因进行分类。评估了母亲的风险因素以及胎儿孕周和体重在死产原因中的作用。单胎死产最常见的原因是致死性先天性异常、胎盘功能不全以及脐带受压环和打结。78%的单胎死产病例可以确定死因,22%无法分类。死产原因在孕周或体重方面无显著差异。吸烟可能会增加胎盘早剥的发生率(P<0.01)。芬兰图尔库死产最常见的原因与其他高收入国家的研究结果一致。通过仔细的尸体解剖检查和辅助研究,大多数病例有可能找到死产原因。即使死产原因不明,也可以排除许多其他有害情况,这对父母和医疗单位都有益。

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