Kapurubandara Supuni, Melov Sarah J, Shalou Evangeline R, Mukerji Monika, Yim Stephen, Rao Ujvala, Battikhi Zain, Karunaratne Nirusha, Nayyar Roshini, Alahakoon Thushari I
Westmead Institute for Maternal and Fetal Medicine, Westmead Hospital, Sydney, New South Wales, Australia.
University of Sydney, Sydney, New South Wales, Australia.
PLoS One. 2017 Feb 13;12(2):e0171829. doi: 10.1371/journal.pone.0171829. eCollection 2017.
It is estimated that everyday 7000 women worldwide have their pregnancy end with a stillbirth, however, research and data collection on stillbirth remains underfunded. This stillbirth case series audit investigates an apparent rise in stillbirths at a Sydney tertiary referral hospital in Australia. A retrospective case series of singleton stillbirths from 2005-2010 was conducted at Westmead Hospital. Stillbirth was defined as per the Perinatal Society of Australia and New Zealand classification as a death of a baby before or during birth, from the 20th week of pregnancy onwards, or a birth weight of 400 grams or more if gestational age is unknown. A total of 215 singleton stillbirths were identified in a cohort of 28 109, a rate of 7.6 per 1000 singleton births. There was a significant increase in annual stillbirth rate at our institution; the rate exceeded both Australian national and state singleton stillbirth rates. After pregnancy terminations over 20 weeks were excluded from the data, there was no statistical change in the stillbirth rate over time. Congenital anomalies (27%) and unexplained antepartum death (15%) remained as major causes; fetal growth restriction (17%) was also identified as an increasingly important cause, particularly in preterm gestations. Termination of pregnancy after 20 weeks was found to be the cause of rising stillbirth rate at our institution. Local and national data collection on stillbirth should be standardised and should include differentiation of termination of pregnancy as a separate entity so as to accurately assess stillbirth to target appropriate research and resource allocation.
据估计,全球每天有7000名女性的妊娠以死产告终,然而,关于死产的研究和数据收集仍然资金不足。本死产病例系列审计调查了澳大利亚悉尼一家三级转诊医院死产明显增加的情况。在韦斯特米德医院对2005年至2010年的单胎死产进行了回顾性病例系列研究。死产的定义按照澳大利亚和新西兰围产医学会的分类,即妊娠20周及以后在出生前或出生期间婴儿死亡,或者如果孕周未知则出生体重400克及以上。在28109例队列中总共确定了215例单胎死产,单胎出生率为每1000例7.6例。我们机构的年度死产率有显著增加;该比率超过了澳大利亚国家和州的单胎死产率。在数据中排除20周以上的妊娠终止后,死产率随时间没有统计学变化。先天性异常(27%)和不明原因的产前死亡(15%)仍然是主要原因;胎儿生长受限(17%)也被确定为一个日益重要的原因,特别是在早产妊娠中。发现20周后妊娠终止是我们机构死产率上升的原因。关于死产的地方和国家数据收集应该标准化,并且应该将妊娠终止作为一个单独的实体进行区分,以便准确评估死产情况,从而确定适当的研究和资源分配目标。