大脑中的肽YY受体。

Peptide YY receptors in the brain.

作者信息

Inui A, Oya M, Okita M, Inoue T, Sakatani N, Morioka H, Shii K, Yokono K, Mizuno N, Baba S

机构信息

Second Department of Internal Medicine, School of Medicine, Kobe University, Japan.

出版信息

Biochem Biophys Res Commun. 1988 Jan 15;150(1):25-32. doi: 10.1016/0006-291x(88)90481-0.

DOI:10.1016/0006-291x(88)90481-0

PMID:2827668

Abstract

Radiolabelled ligand binding studies demonstrated that specific receptors for peptide YY are present in the porcine as well as the canine brains. Peptide YY was bound to brain tissue membranes via high-affinity (dissociation constant, 1.39 X 10(-10)M) and low-affinity (dissociation constant, 3.72 X 10(-8)M) components. The binding sites showed a high specificity for peptide YY and neuropeptide Y, but not for pancreatic polypeptide or structurally unrelated peptides. The specific activity of peptide YY binding was highest in the hippocampus, followed by the pituitary gland, the hypothalamus, and the amygdala of the porcine brain, this pattern being similarly observed in the canine brain. The results suggest that peptide YY and neuropeptide Y may regulate the function of these regions of the brain through interaction with a common receptor site.

摘要

放射性标记配体结合研究表明，猪和犬的大脑中存在肽YY的特异性受体。肽YY通过高亲和力（解离常数为1.39×10⁻¹⁰M）和低亲和力（解离常数为3.72×10⁻⁸M）成分与脑组织膜结合。结合位点对肽YY和神经肽Y具有高度特异性，但对胰多肽或结构不相关的肽没有特异性。肽YY结合的比活性在猪脑的海马体中最高，其次是垂体、下丘脑和杏仁核，在犬脑中也观察到类似的模式。结果表明，肽YY和神经肽Y可能通过与共同的受体位点相互作用来调节大脑这些区域的功能。