Mergens W J, Kamm J J, Newmark H L, Fiddler W, Pensabene J
IARC Sci Publ (1971). 1978(19):199-212.
alpha-Tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-Tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. The use of alpha-tocopherol was shown to inhibit aminopyrene-nitrite induced hepatotoxicity in rats and to reduce the amount of NDMA formed in cigarette smoke. Of primary interest is the finding of a significant reduction of NPYR formation in fried bacon. Nitrosamine inhibition was greater with alpha-tocopherol used in combination with sodium ascorbate than with sodium ascorbate alone.
在模型系统和实际条件下，已对α-生育酚作为亚硝酸盐清除剂预防亚硝胺形成进行了评估。发现α-生育酚在亲脂性和水性环境中均能与亚硝化剂发生反应。已表明使用α-生育酚可抑制大鼠中氨基芘-亚硝酸盐诱导的肝毒性，并减少香烟烟雾中形成的N-亚硝基二甲胺的量。主要关注的是在煎培根中N-亚硝基吡咯烷形成的显著减少这一发现。与单独使用抗坏血酸钠相比，α-生育酚与抗坏血酸钠联合使用时对亚硝胺的抑制作用更强。
