欧洲栗（Castanea sativa Mill.）树皮提取物（ENC®）对衣原体属的体外活性
In vitro activity of a partially purified and characterized bark extract of Castanea sativa Mill. (ENC®) against Chlamydia spp.
作者信息
Papa Valentina, Ginocchietti Laura, Budriesi Roberta, Micucci Matteo, Costa Roberta, Biondi Roberta, Cevenini Roberto, Chiarini Alberto, Aldini Rita, Donati Manuela, Pollini Gian Matteo, Cenacchi Giovanna
机构信息
a Biomedical and Neuromotor Sciences Department, Pathology , University of Bologna , Bologna , Italy.
b Experimental Diagnostic and Specialty Medicine Department, Microbiology , University of Bologna , Bologna , Italy.
出版信息
Ultrastruct Pathol. 2017 Mar-Apr;41(2):147-153. doi: 10.1080/01913123.2016.1275909. Epub 2017 Feb 8.
Castanea sativa Mill (ENC®), containing tannins against 33 Chlamydia strains, was compared to SMAP-29 with inhibitory effect against C. trachomatis and C. pneumoniae. The ENC® activity against Chlamydia spp. was evaluated determining the lowest concentration to achieve more than half reduction of intact chlamydial inclusions versus controls. ENC® reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 induced reductions of C. trachomatis and C. pneumoniae infectivity at 10 µg/mL. A great reduction of C. trachomatis, C. pneumoniae, and C. abortus infectivity was achieved with a 10 µg/mL ENC® concentration, whereas their infectivity was almost inhibited at 100 µg/mL ENC® concentration.
富含针对33种衣原体菌株的单宁酸的欧洲栗（ENC®），与对沙眼衣原体和肺炎衣原体有抑制作用的SMAP-29进行了比较。通过确定相对于对照使完整衣原体包涵体减少超过一半的最低浓度，来评估ENC®对衣原体属的活性。ENC®在1微克/毫升时可减少所有测试的衣原体菌株，而SMAP-29在10微克/毫升时可降低沙眼衣原体和肺炎衣原体的感染性。在10微克/毫升的ENC®浓度下，沙眼衣原体、肺炎衣原体和流产衣原体的感染性大幅降低，而在100微克/毫升的ENC®浓度下，它们的感染性几乎被抑制。
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