Taghdiri Mohammad Mehdi, Omidbeigi Mahmoud, Asaadi Sina, Azargashb Eznollah, Ghofrani Mohammad
Pediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Pediatric Neurology Department, Mofid Children's Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medical Student, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Child Neurol. 2017 Winter;11(1):21-28.
We aimed to find the prognostic factors to detect the patients who fail the treatment of epilepsy, in the early stages of the disease.
MATERIALS &METHODS: This study was done on the epileptic patients attending the Neurology Clinic of Mofid Children's Hospital, Tehran, Iran from September 2013 to October 2014. After defining the criteria for exclusion and inclusion, the patients were divided to two groups based on responding to the medical treatment for their epilepsy and indices were recorded for all the patients to be used in the statistical analyses.
The patients' age ranged from 1 to 15 yr. There was 188 patients with refractory seizure in group 1 (experimental group) and 178 patient with well controlled seizure in group 2(control group).There was a significant different between serum drug level in both groups and patients with refractory seizure group had a lower serum drug level than control group. In both groups tonic-clonic was the most common type of seizure. Also the prevalence of brain imaging Abnormalityand other neurologic disorders was significantly higher in patients with refractory seizure in compare with control group.
Children with seizure who suffer from refractory epilepsy need more attention and exact observation by the medical staff.
我们旨在寻找预后因素，以便在癫痫疾病的早期阶段检测出治疗失败的患者。
本研究对2013年9月至2014年10月在伊朗德黑兰莫菲德儿童医院神经科门诊就诊的癫痫患者进行。在确定排除和纳入标准后，根据对癫痫药物治疗的反应将患者分为两组，并记录所有患者的指标以用于统计分析。
患者年龄在1至15岁之间。第1组（实验组）有188例难治性癫痫发作患者，第2组（对照组）有178例癫痫发作得到良好控制的患者。两组患者的血清药物水平存在显著差异，难治性癫痫发作组的血清药物水平低于对照组。在两组中，强直阵挛发作是最常见的发作类型。此外，与对照组相比，难治性癫痫发作患者的脑成像异常和其他神经系统疾病的患病率显著更高。
患有难治性癫痫的癫痫患儿需要医护人员给予更多关注和精确观察。
