耐药性癫痫的识别。
Identification of pharmacoresistant epilepsy.
机构信息
Department of Biology, Northern Illinois University, DeKalb, IL 60115, USA.
出版信息
Neurol Clin. 2009 Nov;27(4):1003-1013. doi: 10.1016/j.ncl.2009.06.001.
Abstract
There is no single definition of pharmacoresistant (intractable, refractory) epilepsy. Prospective identification of pharmacoresistance is complicated by the variability of its appearance across different types of epilepsy and the variability of seizure control within a given patient over time. Failure of informative trials of two appropriate antiepileptic drugs has been recommended as a threshold that should trigger referral for evaluation at a comprehensive epilepsy center. Maximizing seizure control is imperative for reducing the risks and consequences of epilepsy, including the cognitive and psychiatric comorbidities and even sudden death.
摘要
耐药性（难治性、顽固性）癫痫尚无明确的定义。耐药性出现的表现形式在不同类型的癫痫中存在差异，且在同一患者中随时间的推移其癫痫发作控制情况也存在差异，因此前瞻性确定耐药性较为复杂。建议将两种合适抗癫痫药物的信息性试验失败作为触发因素，以促使患者转诊到综合癫痫中心进行评估。最大限度地控制癫痫发作对于降低癫痫的风险和后果至关重要，包括认知和精神共病，甚至猝死。
相似文献
1
Identification of pharmacoresistant epilepsy.耐药性癫痫的识别。
Neurol Clin. 2009 Nov;27(4):1003-1013. doi: 10.1016/j.ncl.2009.06.001.
2
Predicting pharmacoresistance in pediatric epilepsy.预测儿科癫痫的药物耐药性。
Epilepsia. 2013 May;54 Suppl 2:19-22. doi: 10.1111/epi.12179.
3
[Drug-resistant epilepsy].[耐药性癫痫]
Tidsskr Nor Laegeforen. 2009 Oct 8;129(19):1986-9. doi: 10.4045/tidsskr.08.0701.
4
FALSE PHARMACORESISTANCE - A TRUE PROBLEM.假性药物抵抗——一个真实存在的问题。
Acta Clin Croat. 2021 Dec;60(Suppl 3):9-15. doi: 10.20471/acc.2021.60.s3.01.
5
Pharmacoresistance and the role of surgery in difficult to treat epilepsy.药物抵抗和手术在难治性癫痫中的作用。
Nat Rev Neurol. 2012 Dec;8(12):669-77. doi: 10.1038/nrneurol.2012.181. Epub 2012 Sep 11.
6
Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy.维拉帕米在一名难治性癫痫患者中作为潜在P-糖蛋白抑制剂的应用。
Ann Pharmacother. 2004 Oct;38(10):1631-4. doi: 10.1345/aph.1E068. Epub 2004 Aug 24.
7
The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs.抗癫痫药物耐药的固有严重性假说。
Epilepsia. 2013 May;54 Suppl 2:33-40. doi: 10.1111/epi.12182.
8
[Treatment of pharmacoresistant epilepsy: stimulated refractoriness].[药物难治性癫痫的治疗：激发难治性]
Rev Med Suisse. 2012 May 2;8(339):930, 932-4.
9
Pharmacology aspects during transition and at transfer in patients with epilepsy.癫痫患者病情转变及转诊过程中的药理学问题。
Epilepsia. 2014 Aug;55 Suppl 3:8-11. doi: 10.1111/epi.12708.
10
Diagnosing and predicting refractory epilepsy.诊断和预测难治性癫痫。
Acta Neurol Scand Suppl. 2005;181:36-9. doi: 10.1111/j.1600-0404.2005.00507.x.
引用本文的文献
1
Identifying Postural Instability in Children with Cerebral Palsy Using a Predictive Model: A Longitudinal Multicenter Study.使用预测模型识别脑瘫儿童的姿势不稳：一项纵向多中心研究
Diagnostics (Basel). 2023 Jun 20;13(12):2126. doi: 10.3390/diagnostics13122126.
2
Prediction Model for Identifying Computational Phenotypes of Children with Cerebral Palsy Needing Neurotoxin Treatments.识别需要神经毒素治疗的脑瘫儿童计算表型的预测模型。
Toxins (Basel). 2022 Dec 28;15(1):20. doi: 10.3390/toxins15010020.
3
Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition.人类皮质中间神经元经过专门优化以进行移植，可特异性地整合、终止癫痫发作，并显示出长期疗效而不会过度抑制。
Neuron. 2023 Mar 15;111(6):807-823.e7. doi: 10.1016/j.neuron.2022.12.014. Epub 2023 Jan 9.
4
Prediction Model for Identifying Factors Associated with Epilepsy in Children with Cerebral Palsy.识别脑瘫患儿癫痫相关因素的预测模型
Children (Basel). 2022 Dec 8;9(12):1918. doi: 10.3390/children9121918.
5
Evaluation of the efficacy and tolerability of levetiracetam as add-on therapy in intractable epilepsy of children.左乙拉西坦作为儿童难治性癫痫附加治疗的疗效和耐受性评估。
Iran J Child Neurol. 2022 Spring;16(2):77-84. doi: 10.22037/ijcn.v15i4.29028. Epub 2022 Mar 14.
6
Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy.左乙拉西坦治疗癫痫的临床评价。
J Healthc Eng. 2022 Apr 5;2022:3789516. doi: 10.1155/2022/3789516. eCollection 2022.
7
Changes in Pre- and Postsurgery for Drug Resistant Epilepsy: Cognition and Sleep.耐药性癫痫术前术后的变化：认知和睡眠。
Biomed Res Int. 2022 Jan 21;2022:9971780. doi: 10.1155/2022/9971780. eCollection 2022.
8
Suspend or amend? Randomized controlled trial on neuropsychological rehabilitation for epilepsy: A COVID-19 impact.暂停还是修改？癫痫神经心理康复的随机对照试验：COVID-19的影响
Epilepsy Behav Rep. 2022;17:100516. doi: 10.1016/j.ebr.2021.100516. Epub 2021 Dec 16.
9
Neural fragility as an EEG marker of the seizure onset zone.神经脆弱性作为癫痫发作起始区的脑电图标志物。
Nat Neurosci. 2021 Oct;24(10):1465-1474. doi: 10.1038/s41593-021-00901-w. Epub 2021 Aug 5.
10
An integrative prediction algorithm of drug-refractory epilepsy based on combined clinical-EEG functional connectivity features.基于联合临床-EEG 功能连接特征的药物难治性癫痫综合预测算法。
J Neurol. 2022 Mar;269(3):1501-1514. doi: 10.1007/s00415-021-10718-z. Epub 2021 Jul 25.
本文引用的文献
1
Remission of epilepsy after two drug failures in children: a prospective study.儿童两次药物治疗失败后癫痫的缓解：一项前瞻性研究。
Ann Neurol. 2009 May;65(5):510-9. doi: 10.1002/ana.21642.
2
Drowning in people with epilepsy: how great is the risk?癫痫患者的溺水情况：风险有多大？
Neurology. 2008 Aug 19;71(8):578-82. doi: 10.1212/01.wnl.0000323813.36193.4d.
3
The prevalence of epilepsy and pharmacoresistant epilepsy in adults: a population-based study in a Western European country.成人癫痫和药物抵抗性癫痫的患病率：一项在西欧某国开展的基于人群的研究。
Epilepsia. 2008 Jul;49(7):1230-8. doi: 10.1111/j.1528-1167.2008.01579.x.
4
Depression in epilepsy: a complex relation with unexpected consequences.癫痫中的抑郁：一种有着意想不到后果的复杂关系。
Curr Opin Neurol. 2008 Apr;21(2):190-4. doi: 10.1097/WCO.0b013e3282f4e978.
5
Treatment of pediatric epilepsy: European expert opinion, 2007.儿童癫痫的治疗：欧洲专家意见，2007年
Epileptic Disord. 2007 Dec;9(4):353-412. doi: 10.1684/epd.2007.0144.
6
Global cognitive function in children with epilepsy: a community-based study.癫痫患儿的整体认知功能：一项基于社区的研究。
Epilepsia. 2008 Apr;49(4):608-14. doi: 10.1111/j.1528-1167.2007.01461.x. Epub 2007 Dec 6.
7
GLUT1 deficiency syndrome--2007 update.葡萄糖转运蛋白1缺乏综合征——2007年更新版
Dev Med Child Neurol. 2007 Sep;49(9):707-16. doi: 10.1111/j.1469-8749.2007.00707.x.
8
Diagnostic utility of an epilepsy monitoring unit.癫痫监测单元的诊断效用。
Am J Med Qual. 2007 Mar-Apr;22(2):117-22. doi: 10.1177/1062860606298295.
9
The development of intellectual abilities in pediatric temporal lobe epilepsy.小儿颞叶癫痫患者智力能力的发展
Epilepsia. 2007 Jan;48(1):201-4. doi: 10.1111/j.1528-1167.2006.00904.x.
10
Stiripentol.司替戊醇
Neurotherapeutics. 2007 Jan;4(1):123-5. doi: 10.1016/j.nurt.2006.10.001.
Zotero 插件