Wang Jing-Wen, Chen Jia-Yan, Lu Chen, Tang Xi
a Department of Oncology , Huadong Hospital Affiliated to Fudan University , Shanghai , P.R. China.
b Department of Pathology , Huadong Hospital Affiliated to Fudan University , Shanghai , P.R. China.
Cancer Biol Ther. 2017 Apr 3;18(4):201-202. doi: 10.1080/15384047.2017.1294293. Epub 2017 Feb 25.
Reports of sequential occurrence of two or more types of lymphoma are rare, especially when they involve different cell lineages. Herein, we report a rare case of sequential development of peripheral t-cell lymphoma following treatment of diffuse large B cell lymphoma. In a 73-year-old Chinese male patient, diffuse large B-cell lymphoma (DLBCL) was diagnosed in September 2011 based on the result of a tongue biopsy. Afterwards, he received rituximab combined with chemotherapy and local radiotherapy. Though he achieved completed remission, he had a new symptom of one enlarged left inguinal lymph node in November of 2015. A new biopsy was then performed. Immunohistochemistry and polymerase chain reaction (PCR) for gene rearrangements proved monoclonal T-cell lymphoma. We didn't detect EBV infection in either of two biopsies, nor any evidence of immune dysfunction complications. Sequential development of B-cell and T-cell malignancy in this patient maybe an example of treatment-related secondary lymphoma.
关于两种或更多类型淋巴瘤相继发生的报道很少见，尤其是当它们涉及不同细胞谱系时。在此，我们报告一例罕见病例，一名患者在弥漫性大B细胞淋巴瘤治疗后相继发生外周T细胞淋巴瘤。一名73岁的中国男性患者，根据舌活检结果于2011年9月被诊断为弥漫性大B细胞淋巴瘤（DLBCL）。此后，他接受了利妥昔单抗联合化疗及局部放疗。尽管达到了完全缓解，但在2015年11月他出现了新症状，左侧腹股沟淋巴结肿大。随后进行了新的活检。免疫组织化学及基因重排的聚合酶链反应（PCR）证实为单克隆T细胞淋巴瘤。在两次活检中均未检测到EBV感染，也没有任何免疫功能障碍并发症的证据。该患者B细胞和T细胞恶性肿瘤的相继发生可能是治疗相关继发性淋巴瘤的一个例子。
