Schulman J A, Peyman G, Fiscella R, Small G, Coats M, Wajszczuk C P, Steahly L
Department of Ophthalmology, University of Texas Medical Branch, Galveston.
Can J Ophthalmol. 1987 Oct;22(6):304-6.
Fluconazole is a new bis-triazole derivative proven highly effective against Candida in various animal models. To determine its potential use in exogenous fungal endophthalmitis, 13 New Zealand white rabbits were given intravitreal injections of up to 100 micrograms/0.1 mL of the antifungal. All eyes underwent biomicroscopy, ophthalmoscopy and electroretinography before and after the procedure. No evidence of toxic intraocular effects was detected with these techniques or on light microscopy, performed 8 days after injection. The results suggest that fluconazole has potential application in the treatment of exogenous fungal endophthalmitis.
氟康唑是一种新型双三唑衍生物，已证实在各种动物模型中对念珠菌具有高效性。为确定其在外源性真菌性眼内炎中的潜在用途，对13只新西兰白兔进行了玻璃体内注射，注射量高达100微克/0.1毫升抗真菌药。所有眼睛在手术前后均接受了生物显微镜检查、检眼镜检查和视网膜电图检查。在注射8天后进行的这些检查以及光学显微镜检查中，均未发现眼内有毒性作用的证据。结果表明，氟康唑在外源性真菌性眼内炎的治疗中具有潜在应用价值。
