Wilson B D, Sohnle P G
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
Clin Immunol Immunopathol. 1988 Feb;46(2):284-93. doi: 10.1016/0090-1229(88)90190-0.
Mice deficient in the fifth component of complement were studied for their ability to respond to and clear experimental cutaneous Candida albicans infections. The complement-deficient animals took longer to clear the infections and developed a significantly greater delayed hypersensitivity response to Candida than did normal animals. However, although the serum of the complement-deficient animals was incapable of generating in vitro chemotactic activity for neutrophils after appropriate stimulation, the epidermal neutrophilic infiltrate in the Candida-infected skin of these animals was equivalent to that in the normal animals. The progression of the infection, including the early relocation of the invading Candida pseudohyphae to a more superficial site in the stratum corneum and the thickening of the epidermis itself, was also similar in the complement-deficient and normal animals. Therefore, although mice lacking the fifth complement component cannot generate complement-derived serum chemotactic factors and are somewhat less efficient in clearing experimental cutaneous candidiasis, the accumulation of neutrophils in the Candida-infected skin of these animals and their initial cutaneous responses to the infections are normal.
对缺乏补体第五成分的小鼠进行了研究，以观察它们对实验性皮肤白色念珠菌感染的反应和清除能力。与正常动物相比，缺乏补体的动物清除感染的时间更长，并且对念珠菌产生的迟发型超敏反应明显更强。然而，尽管在适当刺激后，缺乏补体动物的血清无法在体外产生对中性粒细胞的趋化活性，但这些动物念珠菌感染皮肤中的表皮嗜中性粒细胞浸润与正常动物相当。在缺乏补体和正常的动物中，感染的进展，包括入侵的念珠菌假菌丝早期重新定位到角质层中更浅表的部位以及表皮本身的增厚，也是相似的。因此，尽管缺乏补体第五成分的小鼠不能产生补体衍生的血清趋化因子，并且在清除实验性皮肤念珠菌病方面效率略低，但这些动物念珠菌感染皮肤中嗜中性粒细胞的积聚及其对感染的初始皮肤反应是正常的。
