Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
Cell Host Microbe. 2017 Mar 8;21(3):312-314. doi: 10.1016/j.chom.2017.02.011.
Dengue hemorrhagic fever is shown to correlate with secondary infection with a virus serotype different from the previous infection. However, only a small fraction of secondary infections leads to hemorrhagic fever. A recent Science paper suggests that the fucosylation state and isotype of IgGs elicited in patients may enhance disease severity.
登革出血热与先前感染不同型别的病毒的继发感染相关。然而，仅有一小部分继发感染会导致出血热。最近的一篇《科学》论文表明，患者中产生的 IgGs 的岩藻糖基化状态和同种型可能会增强疾病的严重程度。
