Finet Jose Emanuel
Krannert Institute of Cardiology, Indiana University, IU Health Methodist Hospital, 1801 North Senate Boulevard, MPC-2, Suite 2000, Indianapolis, IN 46202, USA.
Heart Fail Clin. 2017 Apr;13(2):253-288. doi: 10.1016/j.hfc.2016.12.004.
The number of cancer survivors increases annually, because of advances in detection and treatment, and the aging and growth of the population. This increase has brought a concomitant increase in morbidity and mortality from other conditions related to the adverse effects of cancer treatments. Cardiovascular diseases, and in particular left ventricular dysfunction and heart failure, are among the most significant of these. There are no unified and universally accepted evidence-based practice guidelines on the management of heartfailure in this population. This article discusses the epidemiologic impact of cancer therapeutics-related cardiac dysfunction, and reviews its most significant mediators and provides a condensed but comprehensive synopsis on its evaluation and management.
由于检测和治疗技术的进步以及人口老龄化和增长,癌症幸存者的数量逐年增加。这一增长带来了与癌症治疗副作用相关的其他疾病的发病率和死亡率的相应增加。心血管疾病,尤其是左心室功能障碍和心力衰竭,是其中最显著的疾病。对于这一人群的心力衰竭管理,目前尚无统一且被普遍接受的循证实践指南。本文讨论了癌症治疗相关心脏功能障碍的流行病学影响,回顾了其最重要的介导因素,并对其评估和管理提供了简洁而全面的概述。