重症肌无力免疫球蛋白G对小鼠膈肌神经肌肉传递的影响。

The effects of myasthenic immunoglobulin G on neuromuscular transmission in mouse diaphragm.

作者信息

Chiu H C, Chen M L, Tsai M C

机构信息

Department of Neurology, College of Medicine, National Taiwan University, Taipei, ROC.

出版信息

Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1987 Aug;20(3):217-23.

PMID:2827968

Abstract

The effect of immunoglobulin G (IgG) from a patient with myasthenia gravis (MG) on neuromuscular transmission of an isolated mouse diaphragm preparation was studied by using electrophysiological methods. The frequency and amplitude of miniature endplate potentials (MEPPs) of the diaphragms obtained from mice injected intraperitoneally with purified IgG from MG patient were reduced by about 13% and 20%, respectively in comparison with results from normal mouse diaphragms. The amplitude of endplate potential (EPP) and the quantal content of EPPs were also reduced by about 21% and 7%, respectively. No significant changes in EPP and MEPP amplitudes were seen in the diaphragms of mice injected with normal IgG serum. It is postulated IgG from myasthenia gravis acts to interfere with both the receptor and the nerve terminal functions.

摘要

采用电生理方法研究了重症肌无力（MG）患者的免疫球蛋白G（IgG）对分离的小鼠膈肌标本神经肌肉传递的影响。与正常小鼠膈肌相比，腹腔注射MG患者纯化IgG的小鼠膈肌微小终板电位（MEPPs）的频率和幅度分别降低了约13%和20%。终板电位（EPP）的幅度和EPPs的量子含量也分别降低了约21%和7%。注射正常IgG血清的小鼠膈肌中EPP和MEPP幅度未见明显变化。推测重症肌无力患者的IgG会干扰受体和神经末梢的功能。