慢性感染所致肠炎沙门氏菌鼠伤寒血清型菌尿症的基因组异质性
Genomic heterogeneity of Salmonella enterica serovar Typhimurium bacteriuria from chronic infection.
作者信息
Octavia Sophie, Wang Qinning, Tanaka Mark M, Sintchenko Vitali, Lan Ruiting
机构信息
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
Centre for Infectious Diseases and Microbiology-Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia.
出版信息
Infect Genet Evol. 2017 Jul;51:17-20. doi: 10.1016/j.meegid.2017.03.004. Epub 2017 Mar 7.
We sequenced the genomes of 14 sequential Salmonella enterica serovar Typhimurium isolates obtained over a five year period from a patient with persistent Salmonella bacteriuria. The isolates formed five distinct lineages; two of which co-existed over four years. We inferred that the observed within-patient variation resulted from mutation events.
我们对从一名患有持续性沙门氏菌菌尿症的患者身上，在五年时间内获得的14株连续的肠炎沙门氏菌鼠伤寒血清型菌株进行了基因组测序。这些菌株形成了五个不同的谱系；其中两个谱系共存了四年。我们推断，观察到的患者体内的变异是由突变事件导致的。
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