Sadr Katayoun, Aghbali Amirala, Sadr Makan, Abachizadeh Hamed, Azizi Maryam, Mesgari Abbasi Mehran
Dept. of Prosthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
J Dent (Shiraz). 2017 Mar;18(1):37-42.
Various researchers have suggested the use of β2-adrenergic receptor antagonists in prevention or treatment of bone resorption.
This study aimed to evaluate the effect of β2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats.
Maxillary first molars of 40 rats were extracted and divided into two groups. The test group received 0.1 mg/kg propranolol intraperitoneally daily. The controls received normal saline. At days 7, 14, 21 and 28 post-extraction, 5 rats were euthanized from each group. Maxillary bone was resected and the mean number of osteoblasts and osteoclasts in tooth socket was measured.
After 1 week, the number of osteoclasts in the controls was significantly higher than the test group. A significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks (< 0.05). The number of osteoblasts in the controls at second week reached its maximum rate but stayed constant in the 3rd and 4th weeks. Osteoblasts in the test group increased similar to the controls but reached its maximum at 3rd week and showed a significant increase compared to the controls (< 0.05).
β2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing.
不同的研究人员已建议使用β2 - 肾上腺素能受体拮抗剂来预防或治疗骨吸收。
本研究旨在评估β2 - 肾上腺素能受体拮抗剂对参与大鼠上颌第一磨牙拔牙窝愈合的破骨细胞和成骨细胞数量的影响。
拔除40只大鼠的上颌第一磨牙并分为两组。试验组每天腹腔注射0.1mg/kg普萘洛尔。对照组注射生理盐水。拔牙后第7、14、21和28天，每组处死5只大鼠。切除上颌骨并测量牙槽窝中成骨细胞和破骨细胞的平均数量。
1周后，对照组破骨细胞数量显著高于试验组。与接下来几周相比，两组在第1周时破骨细胞数量均显著增加（<0.05）。对照组成骨细胞数量在第2周达到最高水平，但在第3周和第4周保持稳定。试验组成骨细胞数量与对照组增加趋势相似，但在第3周达到最高水平，且与对照组相比有显著增加（<0.05）。
β2肾上腺素能受体拮抗剂在拔牙窝愈合过程中可减少破骨细胞数量并增加成骨细胞数量。
