Goh K O, Bauman A, Bakemeier R, Lee H, Woll J E
Am J Med Sci. 1978 Sep-Oct;276(2):189-95. doi: 10.1097/00000441-197809000-00006.
Abnormal chromosomes have been found in various clinical settings and in cancer patients. Eight patients developed leukemia several years after the diagnosis and treatment of a primary malignant disease. All the patients were being treated with irradiation, and five of them also received chemotherapy, notably, alkylating agents. The type of leukemias and the interval between irradiation and leukemia parallel very well with those reported from the atomic bomb casualties. Chromosomal abnormalities were seen in all the patients. These abnormalities have been reported in irradiated normal persons without developed leukemias. These findings suggest that the development of clinical cancer or leukemia may depend, not only on the presence of abnormal cells, but also on other factors. Perhaps the environment that allowed the original cancer to develop in our patients is capable of allowing the radiation-induced abnormal cells to be expressed as clinical leukemia.
在各种临床环境以及癌症患者中均发现了异常染色体。8名患者在原发性恶性疾病诊断和治疗数年后患上了白血病。所有患者均接受了放射治疗，其中5名还接受了化疗，尤其是烷化剂。白血病类型以及放射与白血病之间的间隔时间与原子弹爆炸受害者报告的情况非常相似。所有患者均出现了染色体异常。这些异常在未患白血病的受辐射正常人中也有报告。这些发现表明，临床癌症或白血病的发生可能不仅取决于异常细胞的存在，还取决于其他因素。或许使我们的患者最初患上癌症的环境能够使辐射诱导的异常细胞发展为临床白血病。
