Mikami Takeshi, Kuribara Tomoyoshi, Komatsu Katsuya, Kimura Yusuke, Wanibuchi Masahiko, Houkin Kiyohiro, Mikuni Nobuhiro
a Department of Neurosurgery , Sapporo Medical University , Sapporo , Japan.
b Department of Neurosurgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
Neurol Res. 2017 Aug;39(8):702-708. doi: 10.1080/01616412.2017.1301048. Epub 2017 Mar 10.
Meandering flow void around the splenium, which can be recognized on conventional T2-weighted images, implicates collateral flow in the splenial artery in patients with moyamoya disease. In this report, curves of flow voids around the splenium (SFVs) were evaluated in patients with moyamoya disease, and their diagnostic value and pathophysiology were verified.
A total of 65 consecutive patients with moyamoya disease were included in this analysis. The number of SFV curves was counted on each side. The numbers of SFV curves in patients with moyamoya disease was compared with those in the control group. The clinical features of patients with large numbers of flow voids were analyzed.
The mean number of SFVs was significantly higher in the moyamoya disease group than in the control group or the atherosclerotic disease group. The cut-off SFV count for a diagnosis of moyamoya disease should be set to 2.25 in consideration of receiver operating characteristic curve analysis. A multivariate logistic analysis of SFV data in moyamoya disease revealed significant differences between the high SFV count group (≥2.25) and the low SFV count group (<2.25) in age, flow voids in the basal ganglia, and magnetic resonance angiography score of the internal carotid artery and anterior cerebral artery.
Based on this study, number of SFV curves on conventional T2-weighted imaging could be a useful measurement for confirming a diagnosis of moyamoya disease. Increased number of SFV curves was associated with age and progress of disease.
在传统T2加权图像上可识别的胼胝体周围迂曲的血流空洞，提示烟雾病患者胼胝体动脉存在侧支血流。在本报告中，对烟雾病患者胼胝体周围血流空洞曲线（SFV）进行了评估，并验证了其诊断价值和病理生理学。
本分析共纳入65例连续的烟雾病患者。计算每侧SFV曲线的数量。将烟雾病患者的SFV曲线数量与对照组进行比较。分析血流空洞数量较多患者的临床特征。
烟雾病组的平均SFV数量显著高于对照组或动脉粥样硬化疾病组。考虑到受试者工作特征曲线分析，烟雾病诊断的SFV计数临界值应设定为2.25。对烟雾病患者的SFV数据进行多因素逻辑分析显示，高SFV计数组（≥2.25）和低SFV计数组（<2.25）在年龄、基底节血流空洞以及颈内动脉和大脑前动脉的磁共振血管造影评分方面存在显著差异。
基于本研究，传统T2加权成像上的SFV曲线数量可能是确诊烟雾病的有用测量指标。SFV曲线数量增加与年龄和疾病进展相关。
