Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.
Cell Res. 2017 Apr;27(4):453-454. doi: 10.1038/cr.2017.33. Epub 2017 Mar 10.
Transcriptional activator-like effectors (TALEs) have emerged as powerful tools for genome editing. A recent study published by Cell Research reports that fusion of thioredoxin to TALEs unlocks their full potential in live-cell imaging to accurately analyze genome instability, telomere attrition and epigenetic alterations that are hallmarks of aging.
转录激活样效应因子（TALEs）已成为基因组编辑的有力工具。最近发表在《Cell Research》上的一项研究报告称，将硫氧还蛋白与 TALEs 融合可充分发挥其在活细胞成像中的潜力，从而准确分析基因组不稳定性、端粒损耗和表观遗传改变等衰老的标志性特征。
