Laboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS, PSL Research University, UPMC, Paris, France.
Rep Prog Phys. 2017 Jul;80(7):076601. doi: 10.1088/1361-6633/aa65ef. Epub 2017 Mar 10.
Cells have traditionally been viewed either as independently moving entities or as somewhat static parts of tissues. However, it is now clear that in many cases, multiple cells coordinate their motions and move as collective entities. Well-studied examples comprise development events, as well as physiological and pathological situations. Different ex vivo model systems have also been investigated. Several recent advances have taken place at the interface between biology and physics, and have benefitted from progress in imaging and microscopy, from the use of microfabrication techniques, as well as from the introduction of quantitative tools and models. We review these interesting developments in quantitative cell biology that also provide rich examples of collective out-of-equilibrium motion.
传统上，细胞被视为独立运动的实体或组织中相对静态的部分。然而，现在很明显，在许多情况下，多个细胞协调它们的运动并作为集体实体移动。发育事件以及生理和病理情况都是很好的研究例子。不同的离体模型系统也已经被研究过。生物学和物理学之间的界面也取得了一些最近的进展，并受益于成像和显微镜技术的进步，微制造技术的使用，以及定量工具和模型的引入。我们回顾了这些在定量细胞生物学方面的有趣发展，这些发展也为非平衡集体运动提供了丰富的实例。
