Bouvy Willem H, Kuijf Hugo J, Zwanenburg Jaco J M, Koek Huiberdina L, Kappelle L Jaap, Luijten Peter R, Ikram M Kamran, Biessels Geert Jan
Brain Center Rudolf Magnus, Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands.
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
J Alzheimers Dis. 2017;57(3):705-710. doi: 10.3233/JAD-160952.
Cerebral small vessel disease (SVD) contributes to cognitive impairment and dementia. SVD may affect veins, but veins are difficult to detect with 1.5 and 3T MRI. We compared deep medullary veins (DMVs) visualized on 7T-MRI between patients with early Alzheimer's disease (eAD; n = 17) or amnestic MCI (aMCI; n = 12) and controls (n = 40). The number and density of DMVs was similar in patients and controls, but tortuosity was higher in eAD (Cohen's d = 0.7, 95% CI: 0.1-1.2, p = 0.02) and aMCI (Cohen's d = 0.8, 95% CI: 0.2-1.5, p = 0.01), independent of brain atrophy. Venous changes provide a new perspective on vascular involvement in dementia.
脑小血管病（SVD）会导致认知障碍和痴呆。SVD可能会影响静脉，但在1.5T和3T磁共振成像（MRI）下静脉很难被检测到。我们比较了早期阿尔茨海默病（eAD；n = 17）或遗忘型轻度认知障碍（aMCI；n = 12）患者与对照组（n = 40）在7T-MRI上显示的深部髓质静脉（DMV）。患者和对照组的DMV数量及密度相似，但eAD组（科恩d值= 0.7，95%置信区间：0.1 - 1.2，p = 0.02）和aMCI组（科恩d值= 0.8，95%置信区间：0.2 - 1.5，p = 0.01）的DMV迂曲度更高，且与脑萎缩无关。静脉变化为痴呆中的血管受累提供了新的视角。
