Kim Chanyang, Kim Sehee, Park Seungjoon
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Department of Pharmacology and Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Int J Mol Sci. 2017 Mar 8;18(3):588. doi: 10.3390/ijms18030588.
Mammalian neurogenesis continues throughout adulthood in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus. It is well known that hippocampal neurogenesis is essential in mediating hippocampus-dependent learning and memory. Ghrelin, a peptide hormone mainly synthesized in the stomach, has been shown to play a major role in the regulation of energy metabolism. A plethora of evidence indicates that ghrelin can also exert important effects on neurogenesis in the hippocampus of the adult brain. The aim of this review is to discuss the current role of ghrelin on the in vivo and in vitro regulation of neurogenesis in the adult hippocampus. We will also discuss the possible role of ghrelin in dietary restriction-induced hippocampal neurogenesis and the link between ghrelin-induced hippocampal neurogenesis and cognitive functions.
哺乳动物的神经发生在成年期持续存在于侧脑室的室下区和海马齿状回的颗粒下区。众所周知，海马神经发生在介导依赖海马的学习和记忆中至关重要。胃饥饿素是一种主要在胃中合成的肽类激素，已被证明在能量代谢调节中起主要作用。大量证据表明，胃饥饿素对成年大脑海马区的神经发生也可产生重要影响。本综述的目的是讨论胃饥饿素在成年海马体神经发生的体内和体外调节中的当前作用。我们还将讨论胃饥饿素在饮食限制诱导的海马神经发生中的可能作用，以及胃饥饿素诱导的海马神经发生与认知功能之间的联系。
