Microangiopathic hemolytic anemia in pregnancy.

作者信息

Salhab Mohammed, Hsu Andrew, Ryer Elizabeth, Appiah Juliet, Switzer Bradley

机构信息

University of Massachusetts Medical School, Department of Medicine, United States; University of Massachusetts Medical School, Department of Hematology and Oncology, United States.

University of Massachusetts Medical School, Department of Medicine, United States.

出版信息

Transfus Apher Sci. 2017 Jun;56(3):354-356. doi: 10.1016/j.transci.2017.02.001. Epub 2017 Feb 16.

DOI:10.1016/j.transci.2017.02.001

PMID:28283300

Abstract

Microangipathic hemolytic anemia (MAHA) is a serious diagnosis and difficult to manage in pregnant patients as multiple life threatening conditions could present with MAHA. ADAMTS13 enzyme activity can be affected during pregnancy with multiple factors. A persistent extremely low ADAMTS13 enzyme activity levels, without an inhibitor, after the delivery was an important factor to establish the diagnosis. We present a case of likely congenital ADAMST13 deficiency that manifested for the first time in a pregnant woman at week 37 of pregnancy.

摘要