Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284, INSERM U1081, University of Nice, France; CNRS GDR 3697 Micronit, France.
Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):665-673. doi: 10.1016/j.bbabio.2017.03.002. Epub 2017 Mar 7.
The voltage-dependent anion channel (VDAC) is a pore located at the outer membrane of the mitochondrion. It allows the entry and exit of numerous ions and metabolites between the cytosol and the mitochondrion. Flux through the pore occurs in an active way: first, it depends on the open or closed state and second, on the negative or positive charges of the different ion species passing through the pore. The flux of essential metabolites, such as ATP, determines the functioning of the mitochondria to a noxious stimulus. Moreover, VDAC acts as a platform for many proteins and in so doing supports glycolysis and prevents apoptosis by interacting with hexokinase, or members of the Bcl-2 family, respectively. VDAC is thus involved in the choice the cells make to survive or die, which is particularly relevant to cancer cells. For these reasons, VDAC has become a potential therapeutic target to fight cancer but also other diseases in which mitochondrial metabolism is modified. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.
电压依赖性阴离子通道（VDAC）位于线粒体的外膜上。它允许细胞质和线粒体之间的许多离子和代谢物进出。通过孔的通量以主动方式发生：首先，它取决于孔的打开或关闭状态，其次，取决于通过孔的不同离子种类的负电荷或正电荷。必需代谢物（如 ATP）的通量决定了线粒体对有害刺激的功能。此外，VDAC 作为许多蛋白质的平台，通过与己糖激酶或 Bcl-2 家族成员相互作用，分别支持糖酵解并防止细胞凋亡。因此，VDAC 参与了细胞选择存活或死亡的过程，这对于癌细胞尤其重要。出于这些原因，VDAC 已成为一种潜在的治疗靶点，可用于治疗癌症以及其他线粒体代谢改变的疾病。本文是由 Giuseppe Gasparre、Rodrigue Rossignol 和 Pierre Sonveaux 编辑的题为“癌症中的线粒体”的特刊的一部分。
