Kamminga Jody, Lal Luxshimi, Wright Edwina J, Bloch Mark, Brew Bruce J, Cysique Lucette A
Neuroscience Research Australia, 139 Barker Street, Randwick, NSW, 2031, Australia.
Ongoing and Extended Care Services, Hunter New England Local Health District, Armidale Community Health, Armidale, NSW, 2350, Australia.
Curr HIV/AIDS Rep. 2017 Jun;14(3):83-92. doi: 10.1007/s11904-017-0349-9.
Screening tools to identify HIV-associated neurocognitive disorder (HAND) are primarily devised to detect cognitive impairment on a single occasion. With the chronicity of HIV infection and the risk of HAND developing or progressing despite viral control, it may be pertinent to repeat HAND screening at more than one time point. Despite this, there are limited data on longitudinal use of such screening tools, particularly with regard to the role of practice effects. Additionally, no guidelines currently exist on the timeframe between testing intervals, or recommendation of the magnitude of baseline impairment that warrants follow-up testing. The aim of the current paper was to review existing evidence for longitudinal validity of HAND screening tools. Only those HAND screening tools previously found to have high cross-sectional criterion validity were included. Preliminary recommendations for clinical use and future research are proposed including in international settings.
用于识别HIV相关神经认知障碍（HAND）的筛查工具主要设计用于单次检测认知障碍。鉴于HIV感染的慢性病程以及尽管病毒得到控制仍有HAND发生或进展的风险，在多个时间点重复进行HAND筛查可能是有必要的。尽管如此，关于此类筛查工具纵向使用的数据有限，尤其是关于练习效应的作用。此外，目前尚无关于检测间隔时间框架或值得进行后续检测的基线损伤程度建议的指南。本文的目的是回顾HAND筛查工具纵向有效性的现有证据。仅纳入那些先前被发现具有高横断面标准效度的HAND筛查工具。提出了包括在国际环境中的临床应用和未来研究的初步建议。
