Furasova Aleksandra D, Fakhardo Anna F, Milichko Valentin A, Tervoort Elena, Niederberger Markus, Vinogradov Vladimir V
ITMO University, St. Petersburg 197101, Russian Federation.
ETH Zurich, Department of Materials, Vladimir-Prelog-Weg 5, 8093 Zurich, Switzerland.
Colloids Surf B Biointerfaces. 2017 Jun 1;154:21-26. doi: 10.1016/j.colsurfb.2017.02.029. Epub 2017 Feb 27.
A major obstacle in the introduction of luminescent nanoparticles (NPs) for medical applications is that quantum dots, the most widely studied luminescent materials, despite being biologically safe after coating with a bioshell, still contain a toxic core mostly consisting of semi-conductor NPs, which are not approved by regulatory agencies. Here we point to a potential solution of this problem by using rare-earth (RE) doped hafnia NPs. Hafnia is approved for medical injections as an effective means for the treatment of radiosensitive and radioresistant tumors and can significantly decrease potential toxicity of RE ions. As a step towards the achievement of this goal we describe the development of a bio-friendly method for the preparation of a stable doped hafnia hydrosol with an isoelectric point (IEP) of 8.2, which shows high fluorescence and biocompatibility in regular coagulant tests and cytotoxic assays.
将发光纳米颗粒（NPs）引入医学应用的一个主要障碍是，量子点作为研究最广泛的发光材料，尽管在用生物壳包覆后具有生物安全性，但仍含有主要由半导体纳米颗粒组成的有毒核心，而这些半导体纳米颗粒未得到监管机构的批准。在此，我们指出通过使用稀土（RE）掺杂的氧化铪纳米颗粒来解决这一问题的潜在方法。氧化铪作为治疗放射敏感和放射抗性肿瘤的有效手段已被批准用于医学注射，并且可以显著降低稀土离子的潜在毒性。作为实现这一目标的第一步，我们描述了一种生物友好型方法的开发，该方法用于制备等电点（IEP）为8.2的稳定掺杂氧化铪水溶胶，该水溶胶在常规凝聚试验和细胞毒性测定中显示出高荧光性和生物相容性。
