Zhang Min, Liu Ru-Tao, Zhang Peng, Zhang Na, Yang Chun-Lin, Yue Long-Tao, Li Xiao-Li, Liu Yin, Li Heng, Du Juan, Duan Rui-Sheng
Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
Central laboratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, PR China.
J Neuroimmunol. 2017 Apr 15;305:154-161. doi: 10.1016/j.jneuroim.2017.02.003. Epub 2017 Feb 8.
A growing body of evidence suggests the anti-inflammatory and antitumor effects of parthenolide (PAR). Here we show that PAR treatment inhibits the initiation of experimental autoimmune neuritis (EAN), suppresses the production of TNF-α, IFN-γ, IL-1β and IL-17, and decreases Th1 and Th17 cells at early time point. However, such anti-inflammatory effect vanishes later and PAR impedes the recovery of EAN in late phase, which is accompanied with inhibited apoptosis of inflammatory cells. Our results indicate that PAR plays dual roles in EAN and it is not proper to be applied in autoimmune diseases of nervous system.
越来越多的证据表明小白菊内酯（PAR）具有抗炎和抗肿瘤作用。在此我们表明，PAR处理可抑制实验性自身免疫性神经炎（EAN）的起始，抑制TNF-α、IFN-γ、IL-1β和IL-17的产生，并在早期减少Th1和Th17细胞。然而，这种抗炎作用随后消失，PAR在后期阻碍EAN的恢复，这伴随着炎性细胞凋亡的抑制。我们的结果表明PAR在EAN中起双重作用，并且不适用于神经系统自身免疫性疾病。
