Brown Michael P, Hissaria Pravin, Hsieh Amy Hc, Kneebone Christopher, Vallat Wilson
Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
J Neuroimmunol. 2017 Apr 15;305:16-18. doi: 10.1016/j.jneuroim.2016.12.016. Epub 2017 Jan 18.
Immune checkpoint inhibitors such as Pembrolizumab are used to restore antitumour immune response. It is important to be vigilant of immune mediated adverse events related to such therapy. We report a case of autoimmune limbic encephalitis with Contactin-Associated Protein-like 2 (CASPR2) antibody secondary to Pembrolizumab therapy for metastatic melanoma.
帕博利珠单抗等免疫检查点抑制剂用于恢复抗肿瘤免疫反应。警惕与此类治疗相关的免疫介导不良事件非常重要。我们报告了一例继发于帕博利珠单抗治疗转移性黑色素瘤的伴有Contactin相关蛋白样2（CASPR2）抗体的自身免疫性边缘叶脑炎病例。
