Shirjang Solmaz, Mansoori Behzad, Solali Saeed, Hagh Majid Farshdousti, Shamsasenjan Karim
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Immunol. 2017 May;315:1-10. doi: 10.1016/j.cellimm.2016.12.005. Epub 2016 Dec 26.
Understanding the role of toll-like receptors (TLRs) in the immunomodulation potential, differentiation, migration, and survival of mesenchymal stem cells (MSCs) is absolutely vital to fully exploiting their MSC-based therapeutic potential. Furthermore, through recognition of exogenous or endogenous ligands produced upon injury, TLRs have been linked to allograft rejection and maintenance of chronic inflammatory diseases, including Crohn's disease, rheumatoid arthritis. Characterizing the effect of TLRs in biological control of MSCs fate and function could improve our knowledge about the MSC-based cell therapy and immunotherapy. In this paper, we outline the impacts of TLR activation and mechanisms on MSCs immunomodulatory functions, differentiation, migration, and survivability. Moreover, we indicate that the expression patterns of TLRs in MSCs from different sources.
了解Toll样受体（TLRs）在间充质干细胞（MSCs）的免疫调节潜能、分化、迁移和存活中的作用，对于充分发挥基于MSCs的治疗潜能至关重要。此外，通过识别损伤时产生的外源性或内源性配体，TLRs与同种异体移植排斥反应以及包括克罗恩病、类风湿性关节炎在内的慢性炎症性疾病的维持有关。明确TLRs在MSCs命运和功能的生物学控制中的作用，有助于我们增进对基于MSCs细胞治疗和免疫治疗的认识。在本文中，我们概述了TLR激活及其机制对MSCs免疫调节功能、分化、迁移和生存能力的影响。此外，我们还指出了不同来源MSCs中TLRs的表达模式。
