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古巴共和国脊髓灰质炎的流行病学监测与控制

Epidemiological surveillance and control of poliomyelitis in the Republic of Cuba.

作者信息

Ochoa E G, Lago P M

机构信息

Instituto de Medicina Tropical Pedro Kourí, Ciudad de La Habana, Cuba.

出版信息

J Hyg Epidemiol Microbiol Immunol. 1987;31(4):381-9.

PMID:2828465
Abstract

Organization and performance of Poliomyelitis Epidemiological Surveillance and control in Cuba are described. Since the first vaccination campaign the average of vaccinated population is of 90% and over. Annual and cyclic epidemic peaks disappeared after oral polio vaccination. During 20 years only 7 sporadic cases were diagnosed; the last one in 1979. Surveillance of disease and immunity of infant population was carried out by clinical examination, isolation techniques for Polio and other enteroviruses and by testing neutralizing antibodies in 0-4 years of age population samples from 1963 to 1979. Satisfactory high antibody levels have been maintained up to date after using different combinations of Polio viruses in vaccines and by having regulated the dose intervals. Subsequent virologic investigation in children under age 3, from nurseries of several provincial capitals, leads us to think that there is no Poliovirus circulation in the country. Behavior of the disease and the laboratory finding indicators reveal very successful results in Poliomyelitis elimination programmes.

摘要

描述了古巴脊髓灰质炎流行病学监测与控制的组织和实施情况。自首次疫苗接种运动以来,接种人群的平均比例达到90%及以上。口服脊髓灰质炎疫苗接种后,年度和周期性流行高峰消失。20年间仅诊断出7例散发病例;最后一例发生在1979年。1963年至1979年期间,通过临床检查、脊髓灰质炎和其他肠道病毒的分离技术以及检测0至4岁人群样本中的中和抗体,对婴儿人群的疾病和免疫情况进行了监测。在使用疫苗中不同组合的脊髓灰质炎病毒并规范剂量间隔后,至今仍维持着令人满意的高抗体水平。随后对几个省会城市托儿所中3岁以下儿童进行的病毒学调查使我们认为该国不存在脊髓灰质炎病毒传播。疾病表现和实验室检测指标显示脊髓灰质炎消除计划取得了非常成功的成果。

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