Yang Baode, Li Chenxing, Sun Junyi, Wang Xinghui, Liu Xinling, Yang Chun, Chen Lina, Zhou Jun, Hu Hao
Department of Pharmacology, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Toxicol Appl Pharmacol. 2017 May 1;322:89-96. doi: 10.1016/j.taap.2017.03.006. Epub 2017 Mar 9.
Excessive consumption of alcohol is a well-established risk factor of atrial fibrillation (AF). However, the effects of moderate alcohol drinking remain to be elucidated. This study was designed to determine the effects of moderate ethanol ingestion on atrial fibrillation and the electrophysiological mechanisms. In acetylcholine-induced canine and mouse AF models, the moderate ethanol prevented the generation and persistence of AF through prolonging the latent period of AF and shortening the duration of AF. The action potential duration (APD) was remarkably prolonged under the concentration range of 12.5-50.0mM ethanol in guinea pig atrial myocytes. Ultra-rapid delayed rectified potassium currents (I) were markedly inhibited by 12.5-50.0mM ethanol in a concentration-dependent manner. Ethanol with 50.0mM could inhibit rapid delayed rectifier potassium currents (I). Ethanol under 6.25-50.0mM did not affect on inward rectifier potassium currents (I). Collectively, the present study provided an evidence that moderate ethanol intake can prolong the APD of atrial myocytes by inhibition of I and I, which contributed to preventing the development and duration of AF.
过量饮酒是心房颤动（AF）公认的危险因素。然而，适度饮酒的影响仍有待阐明。本研究旨在确定适度摄入乙醇对心房颤动及其电生理机制的影响。在乙酰胆碱诱导的犬和小鼠房颤模型中，适度乙醇通过延长房颤的潜伏期和缩短房颤的持续时间来预防房颤的发生和持续。在12.5 - 50.0mM乙醇浓度范围内，豚鼠心房肌细胞的动作电位时程（APD）显著延长。12.5 - 50.0mM乙醇以浓度依赖性方式显著抑制超快速延迟整流钾电流（I）。50.0mM乙醇可抑制快速延迟整流钾电流（I）。6.25 - 50.0mM乙醇对内向整流钾电流（I）无影响。总体而言，本研究提供了证据表明适度摄入乙醇可通过抑制I和I来延长心房肌细胞的APD，这有助于预防房颤的发生和持续时间。
