Butragueño Laiseca Laura, Toledo Del Castillo Blanca, Rodríguez Jimenez Cristina, Manrique-Rodríguez Silvia, Pérez Moreno Jimena
Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Eur J Paediatr Neurol. 2017 Jul;21(4):682-684. doi: 10.1016/j.ejpn.2017.01.015. Epub 2017 Feb 11.
Ranitidine has not been considered as a potential cause of ocular movement conditions. However, it is known that the vestibular nucleus complex, that has a key role in gaze control and vestibule-ocular reflexes, receives hypothalamic histaminergic innervations. Some studies reported the effect of ranitidine blocking the excitatory responses of vestibular nuclei neurons to histamine.
We report the first case of a downbeat nystagmus secondary to ranitidine in an infant. A 3-month-old female developed a downbeat gaze after starting treatment with ranitidine for a pediatric gastroesophageal reflux disease. Microbiological test were negative and neuroblastoma evaluation was normal.
As ranitidine is widely prescribed in the pediatric population, clinicians should be aware of its potential to cause ocular movements disorders.
雷尼替丁尚未被视为眼动障碍的潜在病因。然而，已知在凝视控制和前庭眼反射中起关键作用的前庭神经核复合体接受下丘脑组胺能神经支配。一些研究报道了雷尼替丁阻断前庭核神经元对组胺的兴奋性反应的作用。
我们报告了首例婴儿因雷尼替丁导致的下跳性眼球震颤病例。一名3个月大的女性在开始使用雷尼替丁治疗小儿胃食管反流病后出现向下凝视。微生物学检查为阴性，神经母细胞瘤评估正常。
由于雷尼替丁在儿科人群中广泛应用，临床医生应意识到其导致眼动障碍的可能性。
