Chan Yvonne Y, Sandlin Samantha K, Kurzrock Eric A
Department of Urology, University of California Davis Children's Hospital, Sacramento, CA, 95817, USA.
Stem Cell Program, Institute for Regenerative Cures, University of California, Davis Medical Center, 4860 Y Street, Suite 3500, Sacramento, CA, 95817, USA.
Curr Urol Rep. 2017 May;18(5):35. doi: 10.1007/s11934-017-0684-9.
Spina bifida is caused by incomplete neural tube closure during the first trimester. This condition may lead to bowel and bladder dysfunction as well as truncal weakness and motor anomalies. Presentations vary between myelomeningoceles and lipomeningoceles and may result in different outcomes. This review seeks to explore our current understanding of the variations in outcomes between individuals with myelomeningocele and lipomeningocele.
Prenatal intervention has become a standard of care for prenatal diagnoses of myelomeningocele and has been shown to reduce shunt placement and improve motor skills. However, urological benefit from early intervention remains to be seen. Early surgical repair, however, may be beneficial for patients with lipomeningocele. Literature on the urological outcomes of patients with myelomeningocele and lipomeningocele is lacking. Further research is needed to better elucidate differences in long-term urological outcomes between these two pathologies.
脊柱裂是由孕早期神经管闭合不全引起的。这种情况可能导致肠道和膀胱功能障碍以及躯干无力和运动异常。脊髓脊膜膨出和脂肪瘤型脊膜膨出的表现各不相同，可能导致不同的结果。本综述旨在探讨我们目前对脊髓脊膜膨出和脂肪瘤型脊膜膨出患者结局差异的理解。
产前干预已成为脊髓脊膜膨出产前诊断的标准治疗方法，并已被证明可减少分流管置入并改善运动技能。然而，早期干预对泌尿系统的益处仍有待观察。不过，早期手术修复可能对脂肪瘤型脊膜膨出患者有益。缺乏关于脊髓脊膜膨出和脂肪瘤型脊膜膨出患者泌尿系统结局的文献。需要进一步研究以更好地阐明这两种疾病在长期泌尿系统结局方面的差异。
