Ai Lin, Cai Yu-Chun, Lu Yan, Chen Jia-Xu, Chen Shao-Hong
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.
Korean J Parasitol. 2017 Feb;55(1):55-60. doi: 10.3347/kjp.2017.55.1.55. Epub 2017 Feb 28.
Fascioliasis is a foodborne zoonotic parasitic disease. We report 4 cases occurring in the same family, in whom diagnosis of acute fascioliasis was established after series of tests. One case was hospitalized with fever, eosinophilia, and hepatic lesions. MRI showed hypodense changes in both liver lobes. The remaining 3 cases presented with the symptom of stomachache only. Stool analysis was positive for eggs in 2 adult patients. The immunological test and molecular identification of eggs were confirmed at the National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. The results of serological detection were positive in all the 4 patients. DNA sequencing of PCR products of the eggs demonstrated 100% homology with ITS and of . The conditions of the patients were not improved by broad-spectrum anti-parasitic drugs until administration of triclabendazole.
肝片吸虫病是一种食源性人畜共患寄生虫病。我们报告了发生在同一家庭中的4例病例，经一系列检查后确诊为急性肝片吸虫病。其中1例因发热、嗜酸性粒细胞增多和肝脏病变住院治疗。磁共振成像（MRI）显示两叶肝脏均有低密度改变。其余3例仅表现为腹痛症状。粪便分析显示2例成年患者的粪便中虫卵呈阳性。在中国疾病预防控制中心寄生虫病预防控制所（上海）对虫卵进行了免疫学检测和分子鉴定。4例患者的血清学检测结果均为阳性。虫卵聚合酶链反应（PCR）产物的DNA测序显示其内部转录间隔区（ITS）与 的同源性为100%。在使用三氯苯达唑之前，广谱抗寄生虫药物未能改善患者的病情。
