Mørk S J, Rubinstein L J, Kepes J J
Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908.
J Neuropathol Exp Neurol. 1988 Mar;47(2):93-100. doi: 10.1097/00005072-198803000-00002.
Adenoid-like formations resembling ducts and glands or forming a cribriform pattern have previously been described in malignant gliomas, resulting in some cases in a confusion with metastatic adenocarcinoma. The interpretation of these structures as being composed of anaplastic glial cells rests partly on the presence of transitions to more differentiated neoplastic astrocytes and partly on the positivity of some of these cells for glial fibrillary acidic protein. In this report two cases are presented in which the adenoid pattern was associated with papillary formations mimicking the arrangement of a medulloepithelioma. These structures represent a form of aberrant neoplastic differentiation in a malignant glioma rather than the expression of an embryonal neuroepithelial neoplasm.
此前曾在恶性胶质瘤中描述过类似导管和腺体或形成筛状模式的腺样结构，在某些情况下会导致与转移性腺癌混淆。将这些结构解释为由间变性胶质细胞组成，部分基于向更分化的肿瘤性星形胶质细胞的过渡，部分基于其中一些细胞对胶质纤维酸性蛋白呈阳性。在本报告中，展示了两例腺样模式与模仿髓上皮瘤排列的乳头状结构相关的病例。这些结构代表了恶性胶质瘤中一种异常的肿瘤分化形式，而非胚胎性神经上皮肿瘤的表现。
