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汉方药物桂枝茯苓丸在预防化疗引起的周围神经病变方面的潜在应用。

Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy.

作者信息

Cascella Marco, Muzio Maria Rosaria

机构信息

Division of Anesthesia, Department of Anesthesia and Pain Medicine, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, via Mariano Semmola, Naples 80131, Italy.

Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, Asl NA 3 SUD, Torre del Greco, via Marconi, Naples 80059, Italy.

出版信息

J Integr Med. 2017 Mar;15(2):77-87. doi: 10.1016/S2095-4964(17)60313-3.

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and severe adverse effects related to cancer treatment. Unfortunately, although several agents and protocols have been proposed, no prophylactic strategies have yet to be proven useful. Therefore, new alternative therapies have been considered for CIPN prevention. Herbal medicine in Japan, called Kampo medicine, is derived from traditional Chinese medicine. Goshajinkigan (GJG) is a Kampo medicine, that is comprised of ten herbs. The aim of this work is to analyse the results of pre-clinical and clinical studies on the potential applications of GJG in CIPN prevention.

摘要

化疗引起的周围神经病变(CIPN)是癌症治疗相关的最常见且严重的不良反应之一。遗憾的是,尽管已提出了几种药物和方案,但尚无预防性策略被证明有效。因此,人们考虑采用新的替代疗法来预防CIPN。日本的草药医学,即汉方医学,源自传统中医。五积散(GJG)是一种汉方药物,由十种草药组成。这项工作的目的是分析关于GJG在预防CIPN方面潜在应用的临床前和临床研究结果。

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