Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland.
Department of Neurology, Medical University of Lublin, 8 Jaczewski Street, 20-090 Lublin, Poland.
Nutrients. 2022 Jan 31;14(3):625. doi: 10.3390/nu14030625.
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, another opportunity should be taken into consideration-repurposing of the already known medications. As proposed, acetyl-L-carnitine, vitamins (group B and E), extracts of medical plants, including goshajinkigan, curcumin and others, unsaturated fatty acids, as well as the diet composed of so-called "sirtuin-activating foods", could change the typical way of treatment of CIPN, improve the quality of life of patients and maintain the continuity of chemotherapy. This review summarizes currently available data regarding mentioned above agents and evaluates the rationale behind future research focused on their efficacy in CIPN.
化疗引起的周围神经病（CIPN）是化疗的主要且最常见的副作用之一，严重影响患者的生活质量和化疗过程。然而，尽管 CIPN 很常见，但它的管理被认为极具挑战性，因为目前可用的药物通常被认为很难甚至不可能预防这种情况。因此，为诊断出患有这种疾病的患者找到更好的选择是当务之急。在继续寻找新的药物的同时，还应考虑另一种选择——重新利用已有的药物。据提议，乙酰左旋肉碱、维生素（B 族和 E 族）、包括葛根素在内的药用植物提取物、姜黄素和其他物质、不饱和脂肪酸，以及所谓的“长寿激活食物”组成的饮食，可以改变 CIPN 的典型治疗方式，提高患者的生活质量并维持化疗的连续性。本综述总结了目前关于上述药物的可用数据，并评估了未来研究的基本原理，这些研究集中在它们对 CIPN 的疗效上。
