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人类免疫缺陷病毒感染患者的 Tp-e 间期和 Tp-e/QT 比值。

Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus.

机构信息

Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.

Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.

出版信息

J Infect Public Health. 2018 Jan-Feb;11(1):35-38. doi: 10.1016/j.jiph.2017.02.008. Epub 2017 Mar 9.

Abstract

Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were significantly higher in patients with HIV than control subjects (all p<0.01). In correlation analysis, there were positive correlation between Tp-e interval and disease duration (r=0.298, p=0.048). and inverse correlation between Tp-e interval and CD4 count(r=-0.303, p=0.036). Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with HIV than control subjects.

摘要

人类免疫缺陷病毒(HIV)感染和艾滋病已知会导致心血管疾病,如早发冠状动脉疾病、心肌病和心律失常。最近,Tp-e 间期和 Tp-e/QT 比值已被证明是心室复极的新标志物。我们旨在评估 HIV 感染患者的心室复极情况,使用 Tp-e 间期和 Tp-e/QT 比值。共纳入 48 例 HIV 患者和 60 例对照组。从 12 导联心电图测量 Tp-e 间期、Tp-e/QT 和 Tp-e/QTc 比值。HIV 患者的 Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值均显著高于对照组(均 P<0.01)。在相关分析中,Tp-e 间期与疾病持续时间呈正相关(r=0.298,P=0.048),与 CD4 计数呈负相关(r=-0.303,P=0.036)。我们的研究表明,HIV 患者的 Tp-e 间期、Tp-e/QT 和 Tp-e/QTc 比值高于对照组。

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