Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
J Infect Public Health. 2018 Jan-Feb;11(1):35-38. doi: 10.1016/j.jiph.2017.02.008. Epub 2017 Mar 9.
Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were significantly higher in patients with HIV than control subjects (all p<0.01). In correlation analysis, there were positive correlation between Tp-e interval and disease duration (r=0.298, p=0.048). and inverse correlation between Tp-e interval and CD4 count(r=-0.303, p=0.036). Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with HIV than control subjects.
人类免疫缺陷病毒(HIV)感染和艾滋病已知会导致心血管疾病,如早发冠状动脉疾病、心肌病和心律失常。最近,Tp-e 间期和 Tp-e/QT 比值已被证明是心室复极的新标志物。我们旨在评估 HIV 感染患者的心室复极情况,使用 Tp-e 间期和 Tp-e/QT 比值。共纳入 48 例 HIV 患者和 60 例对照组。从 12 导联心电图测量 Tp-e 间期、Tp-e/QT 和 Tp-e/QTc 比值。HIV 患者的 Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值均显著高于对照组(均 P<0.01)。在相关分析中,Tp-e 间期与疾病持续时间呈正相关(r=0.298,P=0.048),与 CD4 计数呈负相关(r=-0.303,P=0.036)。我们的研究表明,HIV 患者的 Tp-e 间期、Tp-e/QT 和 Tp-e/QTc 比值高于对照组。